Bladder cancer in young women

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60 Scopus citations


The authors describe a population-based case-control study of cancer of the urinary bladder in New York State women aged 20-49 years (173 matched pairs) in 1975-1980. Both known and suspected risk factors for bladder cancer were examined for these rare, early-onset female cases. The odds ratio (OR) for cigarette smoking was 2.4 (95% confidence interval (Cl) = 1.5-4.0). Cases consumed more coffee per day than did controls (p <0.05). More cases than controls reported heavy use of drugs that contained phenacetin (OR = 6.5, 95% Cl = 1.5-59.2). In addition, more cases than controls reported that they had had a thyroid uptake procedure with radioactive iodine (iodine-131) (OR = 3.7, 95% Cl = 1.4-11.0). The odds ratios for these factors remained elevated after simultaneous adjustment with conditional logistic regression models. Consumption of artificial sweeteners, occupational history, bladder or kidney cancer in a first-degree relative, and a history of bladder infections were examined and found not to be risk factors for bladder cancer in this study.

Original languageEnglish (US)
Pages (from-to)1033-1042
Number of pages10
JournalAmerican journal of epidemiology
Issue number6
StatePublished - Jun 1986


  • Bladder neoplasms
  • Iodine radioisotopes
  • Phenacetin
  • Smoking

ASJC Scopus subject areas

  • Epidemiology


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