BK virus infection in transplant recipients: An overview and update

P. Randhawa, D. C. Brennan

Research output: Contribution to journalShort surveypeer-review

Abstract

BK virus infection after kidney transplantation has been a subject of great interest in the past decade. This article traces the discovery of BK virus and the subsequent development of our knowledge about this emerging pathogen. The pathobiology of the virus is summarized with particular reference to epidemiology, interactions with host cell receptors, cell entry, cytoplasmic trafficking and targeting of the viral genome to the nucleus. This is followed by a discussion of clinical features, laboratory monitoring and therapeutic strategies. Finally, we present potential cellular mechanisms that explain the basis of virus-mediated damage to the human kidney.

Original languageEnglish (US)
Pages (from-to)2000-2005
Number of pages6
JournalAmerican Journal of Transplantation
Volume6
Issue number9
DOIs
StatePublished - Sep 2006
Externally publishedYes

Keywords

  • BK virus
  • Epidemiology
  • JC virus
  • Kidney
  • Pathobiology
  • Pathogenesis
  • Polyomavirus
  • Renal
  • SV40 virus
  • Transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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