BK polyomavirus reactivation after reduced-intensity double umbilical cord blood cell transplantation

Gowri Satyanarayana, Sarah P. Hammond, Thomas A. Broge, Matthew R. Mackenzie, Raphael Viscidi, Ioannis Politikos, Igor J. Koralnik, Corey S. Cutler, Karen Ballen, Vassiliki Boussiotis, Francisco M. Marty, Chen Sabrina Tan

Research output: Contribution to journalArticlepeer-review

Abstract

Serial serum samples from 27 patients who underwent double umbilical cord blood transplantation (dUCBT) were analyzed for BK polyomavirus (BKPyV) DNA by real-time PCR and BKPyV-specific immune globulin by ELISA. Clinical data were collected on all patients. All pre-transplant sera had detectable anti-BKPyV IgG. Fifteen patients (56%) had detectable serum BKPyV DNA (median 8.9×104copies/ml; range 4.1×103-7.9×106copies/ml) a median of 40days (range, 27-733days) after dUCBT, with highest viral loads on Day 100 assessment. The cumulative probability of developing BKPyV viremia by Day 100 was 0.52 (95% CI, 0.33-0.71). Six of 15 patients with BKPyV viremia experienced hemorrhagic cystitis by Day 100. By Day 100, there was a trend towards higher BKPyV viral loads in sera of patients with hemorrhagic cystitis than in those BKPyV viremic patients without hemorrhagic cystitis (p=0.06). BKPyV viremia was associated with significantly higher anti-BKPyV IgM values at 6months post-dUCBT (P=0.003). BKPyV viremia occurs early after dUBCT and is associated with a detectable humoral immune response by 6months post-dUBCT.

Original languageEnglish (US)
Pages (from-to)116-120
Number of pages5
JournalTransplant Immunology
Volume32
Issue number2
DOIs
StatePublished - Mar 1 2015

Keywords

  • BK polyomavirus
  • Hemorrhagic cystitis
  • Viral reactivation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Transplantation

Fingerprint Dive into the research topics of 'BK polyomavirus reactivation after reduced-intensity double umbilical cord blood cell transplantation'. Together they form a unique fingerprint.

Cite this