BK polyomavirus reactivation after reduced-intensity double umbilical cord blood cell transplantation

Gowri Satyanarayana, Sarah P. Hammond, Thomas A. Broge, Matthew R. Mackenzie, Raphael P Viscidi, Ioannis Politikos, Igor J. Koralnik, Corey S. Cutler, Karen Ballen, Vassiliki Boussiotis, Francisco M. Marty, Chen Sabrina Tan

Research output: Contribution to journalArticle

Abstract

Serial serum samples from 27 patients who underwent double umbilical cord blood transplantation (dUCBT) were analyzed for BK polyomavirus (BKPyV) DNA by real-time PCR and BKPyV-specific immune globulin by ELISA. Clinical data were collected on all patients. All pre-transplant sera had detectable anti-BKPyV IgG. Fifteen patients (56%) had detectable serum BKPyV DNA (median 8.9×104copies/ml; range 4.1×103-7.9×106copies/ml) a median of 40days (range, 27-733days) after dUCBT, with highest viral loads on Day 100 assessment. The cumulative probability of developing BKPyV viremia by Day 100 was 0.52 (95% CI, 0.33-0.71). Six of 15 patients with BKPyV viremia experienced hemorrhagic cystitis by Day 100. By Day 100, there was a trend towards higher BKPyV viral loads in sera of patients with hemorrhagic cystitis than in those BKPyV viremic patients without hemorrhagic cystitis (p=0.06). BKPyV viremia was associated with significantly higher anti-BKPyV IgM values at 6months post-dUCBT (P=0.003). BKPyV viremia occurs early after dUBCT and is associated with a detectable humoral immune response by 6months post-dUBCT.

Original languageEnglish (US)
Pages (from-to)116-120
Number of pages5
JournalTransplant Immunology
Volume32
Issue number2
DOIs
StatePublished - Mar 1 2015

Fingerprint

BK Virus
Cell Transplantation
Fetal Blood
Blood Cells
Viremia
Cystitis
Transplantation
Viral Load
Serum
DNA
Humoral Immunity
Immunoglobulin M
Immunoglobulins
Real-Time Polymerase Chain Reaction
Immunoglobulin G

Keywords

  • BK polyomavirus
  • Hemorrhagic cystitis
  • Viral reactivation

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Transplantation

Cite this

Satyanarayana, G., Hammond, S. P., Broge, T. A., Mackenzie, M. R., Viscidi, R. P., Politikos, I., ... Tan, C. S. (2015). BK polyomavirus reactivation after reduced-intensity double umbilical cord blood cell transplantation. Transplant Immunology, 32(2), 116-120. https://doi.org/10.1016/j.trim.2014.12.002

BK polyomavirus reactivation after reduced-intensity double umbilical cord blood cell transplantation. / Satyanarayana, Gowri; Hammond, Sarah P.; Broge, Thomas A.; Mackenzie, Matthew R.; Viscidi, Raphael P; Politikos, Ioannis; Koralnik, Igor J.; Cutler, Corey S.; Ballen, Karen; Boussiotis, Vassiliki; Marty, Francisco M.; Tan, Chen Sabrina.

In: Transplant Immunology, Vol. 32, No. 2, 01.03.2015, p. 116-120.

Research output: Contribution to journalArticle

Satyanarayana, G, Hammond, SP, Broge, TA, Mackenzie, MR, Viscidi, RP, Politikos, I, Koralnik, IJ, Cutler, CS, Ballen, K, Boussiotis, V, Marty, FM & Tan, CS 2015, 'BK polyomavirus reactivation after reduced-intensity double umbilical cord blood cell transplantation', Transplant Immunology, vol. 32, no. 2, pp. 116-120. https://doi.org/10.1016/j.trim.2014.12.002
Satyanarayana, Gowri ; Hammond, Sarah P. ; Broge, Thomas A. ; Mackenzie, Matthew R. ; Viscidi, Raphael P ; Politikos, Ioannis ; Koralnik, Igor J. ; Cutler, Corey S. ; Ballen, Karen ; Boussiotis, Vassiliki ; Marty, Francisco M. ; Tan, Chen Sabrina. / BK polyomavirus reactivation after reduced-intensity double umbilical cord blood cell transplantation. In: Transplant Immunology. 2015 ; Vol. 32, No. 2. pp. 116-120.
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