Bk and jc virus infections in recipients of bone marrow thinsplants

Ray R. Arthur, Keerti V. Shah, Patricia Charache, Rein Saral

Research output: Contribution to journalArticlepeer-review

Abstract

Fifty-five recipients of bone marrow transplants were monitored prospectively for urinary excretion of BK (BKV) and JC (JCV) viruses and for infections with other viruses. For both BKV and JCV, viruria occurred exclusively in patients who were seropositive at transplantation, a finding indicating that shedding of virus was very likely the result of reactivation. BKV reactivation, which occurred in 26 (55%) of 47 BKV-seropositive patients, was far more common than JCV reactivation, which was detected in only two (7%) of 30 JCV-seropositive patients (P <.0001). In most patients, BK viruria began two to eight weeks after transplantation and resolved spontaneously after a two- to three- week period. Posttransplantation, there was a temporal pattern in the onsets of infection with the different viruses; herpes simplex virus infections occurred first (mean, 7 d), followed by BKV infections (mean, 33 d) and then cytomegalovirus infections (mean, 51 d). BK viruria was associated with hemorrhagic cystitis.

Original languageEnglish (US)
Pages (from-to)563-569
Number of pages7
JournalJournal of Infectious Diseases
Volume158
Issue number3
DOIs
StatePublished - Sep 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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