Bittersweet tumor development and progression

Emerging roles of epithelial plasticity glycosylations

Ryan M. Phillips, Christine Lam, Hailun Wang, Phuoc T Tran

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Altered metabolism is one of the hallmarks of cancer. The best-known cancer metabolic anomaly is an increase in aerobic glycolysis, which generates ATP and other basic building blocks, such as nucleotides, lipids, and proteins to support tumor cell growth and survival. Epithelial plasticity (EP) programs such as the epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) are evolutionarily conserved processes that are essential for embryonic development. EP also plays an important role during tumor progression toward metastasis and treatment resistance, and new roles in the acceleration of tumorigenesis have been found. Recent evidence has linked EMT-related transcriptomic alterations with metabolic reprogramming in cancer cells, which include increased aerobic glycolysis. More recent studies have revealed a novel connection between EMT and altered glycosylation in tumor cells, in which EMT drives an increase in glucose uptake and flux into the hexosamine biosynthetic pathway (HBP). The HBP is a side-branch pathway from glycolysis which generates the end product uridine-5′-diphosphate-N-acetylglucosamine (UDP-GlcNAc). A key downstream utilization of UDP-GlcNAc is for the post-translational modification O-GlcNAcylation which involves the attachment of the GlcNAc moiety to Ser/Thr/Asn residues of proteins. Global changes in protein O-GlcNAcylation are emerging as a general characteristic of cancer cells. In our recent study, we demonstrated that the EMT-HBP-O-GlcNAcylation axis drives the O-GlcNAcylation of key proteins such as c-Myc, which previous studies have shown to suppress oncogene-induced senescence (OIS) and contribute to accelerated tumorigenesis. Here, we review the HBP and O-GlcNAcylation and their putative roles in driving EMT-related cancer processes with examples to illuminate potential new therapeutic targets for cancer.

Original languageEnglish (US)
Title of host publicationAdvances in Cancer Research
PublisherAcademic Press Inc.
DOIs
StatePublished - Jan 1 2019

Publication series

NameAdvances in Cancer Research
ISSN (Print)0065-230X
ISSN (Electronic)2162-5557

Fingerprint

Glycosylation
Epithelial-Mesenchymal Transition
Hexosamines
Biosynthetic Pathways
Neoplasms
Glycolysis
Uridine Diphosphate
Carcinogenesis
Proteins
Uridine Diphosphate N-Acetylglucosamine
Post Translational Protein Processing
Oncogenes
Embryonic Development
Cell Survival
Nucleotides
Adenosine Triphosphate
Neoplasm Metastasis
Lipids
Glucose
Growth

Keywords

  • Epithelial plasticity
  • Epithelial-mesenchymal transition
  • Glycosylation
  • Hexosamine biosynthetic pathway
  • O-GlcNAcylation
  • Oncogene-induced senescence

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Phillips, R. M., Lam, C., Wang, H., & Tran, P. T. (2019). Bittersweet tumor development and progression: Emerging roles of epithelial plasticity glycosylations. In Advances in Cancer Research (Advances in Cancer Research). Academic Press Inc.. https://doi.org/10.1016/bs.acr.2019.01.002

Bittersweet tumor development and progression : Emerging roles of epithelial plasticity glycosylations. / Phillips, Ryan M.; Lam, Christine; Wang, Hailun; Tran, Phuoc T.

Advances in Cancer Research. Academic Press Inc., 2019. (Advances in Cancer Research).

Research output: Chapter in Book/Report/Conference proceedingChapter

Phillips, RM, Lam, C, Wang, H & Tran, PT 2019, Bittersweet tumor development and progression: Emerging roles of epithelial plasticity glycosylations. in Advances in Cancer Research. Advances in Cancer Research, Academic Press Inc. https://doi.org/10.1016/bs.acr.2019.01.002
Phillips RM, Lam C, Wang H, Tran PT. Bittersweet tumor development and progression: Emerging roles of epithelial plasticity glycosylations. In Advances in Cancer Research. Academic Press Inc. 2019. (Advances in Cancer Research). https://doi.org/10.1016/bs.acr.2019.01.002
Phillips, Ryan M. ; Lam, Christine ; Wang, Hailun ; Tran, Phuoc T. / Bittersweet tumor development and progression : Emerging roles of epithelial plasticity glycosylations. Advances in Cancer Research. Academic Press Inc., 2019. (Advances in Cancer Research).
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