TY - JOUR
T1 - Bitot's Spots Responsive and Nonresponsive to Vitamin A
T2 - Clinicopathologic Correlations
AU - Sommer, Alfred
AU - Green, W. Richard
AU - Kenyon, Kenneth R.
PY - 1981/11
Y1 - 1981/11
N2 - Conjunctival biopsy specimens from patients with Bitot's spots responsive and nonresponsive to vitamin A were studied by light and electron microscopy. In both types, the lesions demonstrated keratinization with granular cells, irregular maturation, inflammatory infiltration of the conjunctival substantia propria, and loss of goblet cells. Only in the responsive cases were these changes generalized. Prominent Bitot's spots represented massive accumulations of Gram-positive bacilli and keratin debris. Responsive cases improved histologically within seven days of treatment, and goblet cells began to return within two weeks. These results support our previous suggestions that there is little basis for attempting to differentiate, clinically, between the two types of lesions and that at least some nonresponsive lesions represent a persistent metaplastic change induced during a prior episode of vitamin A deficiency.
AB - Conjunctival biopsy specimens from patients with Bitot's spots responsive and nonresponsive to vitamin A were studied by light and electron microscopy. In both types, the lesions demonstrated keratinization with granular cells, irregular maturation, inflammatory infiltration of the conjunctival substantia propria, and loss of goblet cells. Only in the responsive cases were these changes generalized. Prominent Bitot's spots represented massive accumulations of Gram-positive bacilli and keratin debris. Responsive cases improved histologically within seven days of treatment, and goblet cells began to return within two weeks. These results support our previous suggestions that there is little basis for attempting to differentiate, clinically, between the two types of lesions and that at least some nonresponsive lesions represent a persistent metaplastic change induced during a prior episode of vitamin A deficiency.
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U2 - 10.1001/archopht.1981.03930020890016
DO - 10.1001/archopht.1981.03930020890016
M3 - Article
C2 - 6975096
AN - SCOPUS:0019774810
SN - 0003-9950
VL - 99
SP - 2014
EP - 2027
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 11
ER -