Bone metastases occur frequently in cancer and are commonly associated with bone degradation due to the tumoral production of factors which stimulate the development and activation of osteoclasts. During osteolysis growth factors are released which stimulate tumour growth. Bisphosphonates inhibit osteoclastic bone resorption. Recently, in several large randomised studies of patients with multiple myeloma or bone metastases of breast cancer, long-term treatment with clodronate or pamidronate gave significant bone protection.
|Translated title of the contribution||Bisphosphonates in treatment and prevention of bone metastases|
|Number of pages||6|
|Journal||Nederlands Tijdschrift voor Geneeskunde|
|State||Published - Nov 1997|
ASJC Scopus subject areas