Bisphosphonate use and prevalence of valvular and vascular calcification in women: MESA (The Multi-Ethnic Study of Atherosclerosis)

Sammy Elmariah, Joseph A C Delaney, Kevin D. O'Brien, Matthew J. Budoff, Jens Vogel-Claussen, Valentin Fuster, Richard A. Kronmal, Jonathan L. Halperin

Research output: Contribution to journalArticle

Abstract

Objectives The aim of this study was to determine whether nitrogen-containing bisphosphonate (NCBP) therapy is associated with the prevalence of cardiovascular calcification. Background Cardiovascular calcification correlates with atherosclerotic disease burden. Experimental data suggest that NCBP might limit cardiovascular calcification, which has implications for disease prevention. Methods The relationship of NCBP use to the prevalence of aortic valve, aortic valve ring, mitral annulus, thoracic aorta, and coronary artery calcification (AVC, AVRC, MAC, TAC, and CAC, respectively) detected by computed tomography was assessed in 3,710 women within the MESA (Multi-Ethnic Study of Atherosclerosis) with regression modeling. Results Analyses were age-stratified, because of a significant interaction between age and NCBP use (interaction p values: AVC p <0.0001; AVRC p <0.0001; MAC p = 0.002; TAC p <0.0001; CAC p = 0.046). After adjusting for age; body mass index; demographic data; diabetes; smoking; blood pressure; cholesterol levels; and statin, hormone replacement, and renin-angiotensin inhibitor therapy, NCBP use was associated with a lower prevalence of cardiovascular calcification in women

Original languageEnglish (US)
Pages (from-to)1752-1759
Number of pages8
JournalJournal of the American College of Cardiology
Volume56
Issue number21
DOIs
StatePublished - Nov 16 2010

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Vascular Calcification
Diphosphonates
Atherosclerosis
Nitrogen
Aortic Valve
Thoracic Arteries
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Angiotensins
Thoracic Aorta
Renin
Coronary Vessels
Body Mass Index
Smoking
Cholesterol
Tomography
Demography
Hormones
Blood Pressure
Therapeutics

Keywords

  • bisphosphonate
  • calcification
  • coronary artery
  • valve
  • vascular

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Elmariah, S., Delaney, J. A. C., O'Brien, K. D., Budoff, M. J., Vogel-Claussen, J., Fuster, V., ... Halperin, J. L. (2010). Bisphosphonate use and prevalence of valvular and vascular calcification in women: MESA (The Multi-Ethnic Study of Atherosclerosis). Journal of the American College of Cardiology, 56(21), 1752-1759. https://doi.org/10.1016/j.jacc.2010.05.050

Bisphosphonate use and prevalence of valvular and vascular calcification in women : MESA (The Multi-Ethnic Study of Atherosclerosis). / Elmariah, Sammy; Delaney, Joseph A C; O'Brien, Kevin D.; Budoff, Matthew J.; Vogel-Claussen, Jens; Fuster, Valentin; Kronmal, Richard A.; Halperin, Jonathan L.

In: Journal of the American College of Cardiology, Vol. 56, No. 21, 16.11.2010, p. 1752-1759.

Research output: Contribution to journalArticle

Elmariah, S, Delaney, JAC, O'Brien, KD, Budoff, MJ, Vogel-Claussen, J, Fuster, V, Kronmal, RA & Halperin, JL 2010, 'Bisphosphonate use and prevalence of valvular and vascular calcification in women: MESA (The Multi-Ethnic Study of Atherosclerosis)', Journal of the American College of Cardiology, vol. 56, no. 21, pp. 1752-1759. https://doi.org/10.1016/j.jacc.2010.05.050
Elmariah, Sammy ; Delaney, Joseph A C ; O'Brien, Kevin D. ; Budoff, Matthew J. ; Vogel-Claussen, Jens ; Fuster, Valentin ; Kronmal, Richard A. ; Halperin, Jonathan L. / Bisphosphonate use and prevalence of valvular and vascular calcification in women : MESA (The Multi-Ethnic Study of Atherosclerosis). In: Journal of the American College of Cardiology. 2010 ; Vol. 56, No. 21. pp. 1752-1759.
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