Bisphosphonate Therapy and Atypical Fractures

Anas Saleh, Vishal V. Hegde, Anish G. Potty, Joseph M. Lane

Research output: Contribution to journalReview articlepeer-review


Atypical femoral fractures have attracted a great deal of attention and controversy in the osteoporosis community because of their association with prolonged bisphosphonate therapy. The purpose of this article is to review the epidemiologic evidence linking bisphosphonates to atypical fractures and to highlight the potential pathologic mechanisms involved in such fractures. A management plan is provided based on the available evidence.

Original languageEnglish (US)
Pages (from-to)137-151
Number of pages15
JournalOrthopedic Clinics of North America
Issue number2
StatePublished - Apr 2013
Externally publishedYes


  • Atypical femoral fractures
  • Atypical fractures
  • Bisphosphonate therapy
  • Osteoporosis

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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