Bis(N,N-dimethylcarbamoyloxymethyl) 2', 3'-dideoxyuridine 5'- monophosphate (DM2-ddUMP): A potential ddUMP prodrug

Saeed R. Khan, David Farquhar

Research output: Contribution to journalArticlepeer-review

Abstract

Bis(N,N-dimethylcarbamoyloxymethyl) 2', 3'-dideoxyuridine 5'- monophosphate (DM2-ddUMP) (1a) was synthesized as a potential membrane- permeable prodrug of ddUMP (3). Unlike the bis(pivaloyloxymethyl) analog, 1b, 1a was completely resistant to degradation by plasma enzymes - a property that should enhance its bioavailability.

Original languageEnglish (US)
Pages (from-to)607-610
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number4
DOIs
StatePublished - Jan 22 1999
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Fingerprint Dive into the research topics of 'Bis(N,N-dimethylcarbamoyloxymethyl) 2', 3'-dideoxyuridine 5'- monophosphate (DM2-ddUMP): A potential ddUMP prodrug'. Together they form a unique fingerprint.

Cite this