Bismuth triflate-catalyzed condensation of indoles with acetone

Ganesh M. Shelke; V. Kameshwara Rao; Rakesh K. Tiwari; Bhupender S. Chhikara; Keykavous Parang; Anil Kumar

doi:10.1039/c3ra44693j

Bismuth triflate-catalyzed condensation of indoles with acetone

Ganesh M. Shelke, V. Kameshwara Rao, Rakesh K. Tiwari, Bhupender S. Chhikara, Keykavous Parang, Anil Kumar

Research output: Contribution to journal › Article

Abstract

Reaction of different substituted indoles with acetone was investigated using Bi(OTf)₃ as a catalyst. An efficient protocol was developed for the synthesis of spiro indoles, 1-methyl-cyclopenta[b]indole and bis(1-methyl-1H-indolyl)propanes via the reaction of indole with acetone in the presence of Bi(OTf)₃. The reaction conditions were benign, required shorter reaction time, and gave good yields.

Original language	English (US)
Pages (from-to)	22346-22352
Number of pages	7
Journal	RSC Advances
Volume	3
Issue number	44
DOIs	https://doi.org/10.1039/c3ra44693j
State	Published - 2013
Externally published	Yes

ASJC Scopus subject areas

Chemical Engineering(all)
Chemistry(all)

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abstract = "Reaction of different substituted indoles with acetone was investigated using Bi(OTf)3 as a catalyst. An efficient protocol was developed for the synthesis of spiro indoles, 1-methyl-cyclopenta[b]indole and bis(1-methyl-1H-indolyl)propanes via the reaction of indole with acetone in the presence of Bi(OTf)3. The reaction conditions were benign, required shorter reaction time, and gave good yields.",

author = "Shelke, {Ganesh M.} and Rao, {V. Kameshwara} and Tiwari, {Rakesh K.} and Chhikara, {Bhupender S.} and Keykavous Parang and Anil Kumar",

year = "2013",

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AU - Shelke, Ganesh M.

AU - Rao, V. Kameshwara

AU - Tiwari, Rakesh K.

AU - Chhikara, Bhupender S.

AU - Parang, Keykavous

AU - Kumar, Anil

PY - 2013

Y1 - 2013

N2 - Reaction of different substituted indoles with acetone was investigated using Bi(OTf)3 as a catalyst. An efficient protocol was developed for the synthesis of spiro indoles, 1-methyl-cyclopenta[b]indole and bis(1-methyl-1H-indolyl)propanes via the reaction of indole with acetone in the presence of Bi(OTf)3. The reaction conditions were benign, required shorter reaction time, and gave good yields.

AB - Reaction of different substituted indoles with acetone was investigated using Bi(OTf)3 as a catalyst. An efficient protocol was developed for the synthesis of spiro indoles, 1-methyl-cyclopenta[b]indole and bis(1-methyl-1H-indolyl)propanes via the reaction of indole with acetone in the presence of Bi(OTf)3. The reaction conditions were benign, required shorter reaction time, and gave good yields.

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