Bismuth labeling for the CT assessment of local administration of magnetic nanoparticles

S. Veintemillas-Verdaguer, Y. Luengo, C. J. Serna, M. Andrés-Vergés, M. Varela, Macarena Calero, Ana Lazaro-Carrillo, Angeles Villanueva, Alejandro Sisniega Crespo, P. Montesinos, M. P. Morales

Research output: Contribution to journalArticle

Abstract

Many therapeutic applications of magnetic nanoparticles involve the local administration of nanometric iron oxide based materials as seeds for magnetothermia or drug carriers. A simple and widespread way of controlling the process using x-ray computed tomography (CT) scanners is desirable. The combination of iron and bismuth in one entity will increase the atenuation of xrays, offering such a possibility. In order to check this possibility core-shell nanocrystals of iron oxide@bismuth oxide have been synthesized by an aqueous route and stabilized in water by polyethylene glycol (PEG), and we have evaluated their ability to generate contrast by CT and magnetic resonance imaging (MRI) to measure the radiopacity and proton relaxivities using phantoms. High-resolution scanning transmission electron microscopy (STEM) revealed that the material consists of a highly crystalline 8 nm core of maghemite and a 1 nm shell of bismuth atoms either isolated or clustered on the nanocrystal's surface. The comparison of μCT and MRI images of mice acquired in the presence of the contrast shows that when local accumulations of the magnetic nanoparticles take place, CT images are more superior in the localization of the magnetic nanoparticles than MRI images, which results in magnetic field inhomogeneity artifacts.

Original languageEnglish (US)
Article number135101
JournalNanotechnology
Volume26
Issue number13
DOIs
StatePublished - Mar 11 2015
Externally publishedYes

Fingerprint

Bismuth
Labeling
Tomography
Magnetic resonance
Nanoparticles
Iron oxides
Imaging techniques
Nanocrystals
Drug Carriers
Polyethylene glycols
Seed
Protons
Iron
Magnetic fields
Crystalline materials
Transmission electron microscopy
X rays
Atoms
Scanning electron microscopy
Oxides

Keywords

  • Computed tomography
  • Iron bismuth nanocrystals
  • Magnetic properties
  • Magnetic resonance imaging
  • Radiopacity
  • Surface modification

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

Cite this

Veintemillas-Verdaguer, S., Luengo, Y., Serna, C. J., Andrés-Vergés, M., Varela, M., Calero, M., ... Morales, M. P. (2015). Bismuth labeling for the CT assessment of local administration of magnetic nanoparticles. Nanotechnology, 26(13), [135101]. https://doi.org/10.1088/0957-4484/26/13/135101

Bismuth labeling for the CT assessment of local administration of magnetic nanoparticles. / Veintemillas-Verdaguer, S.; Luengo, Y.; Serna, C. J.; Andrés-Vergés, M.; Varela, M.; Calero, Macarena; Lazaro-Carrillo, Ana; Villanueva, Angeles; Sisniega Crespo, Alejandro; Montesinos, P.; Morales, M. P.

In: Nanotechnology, Vol. 26, No. 13, 135101, 11.03.2015.

Research output: Contribution to journalArticle

Veintemillas-Verdaguer, S, Luengo, Y, Serna, CJ, Andrés-Vergés, M, Varela, M, Calero, M, Lazaro-Carrillo, A, Villanueva, A, Sisniega Crespo, A, Montesinos, P & Morales, MP 2015, 'Bismuth labeling for the CT assessment of local administration of magnetic nanoparticles', Nanotechnology, vol. 26, no. 13, 135101. https://doi.org/10.1088/0957-4484/26/13/135101
Veintemillas-Verdaguer S, Luengo Y, Serna CJ, Andrés-Vergés M, Varela M, Calero M et al. Bismuth labeling for the CT assessment of local administration of magnetic nanoparticles. Nanotechnology. 2015 Mar 11;26(13). 135101. https://doi.org/10.1088/0957-4484/26/13/135101
Veintemillas-Verdaguer, S. ; Luengo, Y. ; Serna, C. J. ; Andrés-Vergés, M. ; Varela, M. ; Calero, Macarena ; Lazaro-Carrillo, Ana ; Villanueva, Angeles ; Sisniega Crespo, Alejandro ; Montesinos, P. ; Morales, M. P. / Bismuth labeling for the CT assessment of local administration of magnetic nanoparticles. In: Nanotechnology. 2015 ; Vol. 26, No. 13.
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