Birth of a new gene on the Y chromosome of Drosophila melanogaster

Antonio Bernardo Carvalho, Beatriz Vicoso, Claudia A M Russo, Bonnielin Swenor, Andrew G. Clark

Research output: Contribution to journalArticle

Abstract

Contrary to the pattern seen in mammalian sex chromosomes, where most Y-linked genes have X-linked homologs, the Drosophila X and Y chromosomes appear to be unrelated. Most of the Y-linked genes have autosomal paralogs, so autosome-to-Y transposition must be the main source of Drosophila Y-linked genes. Here we show how these genes were acquired. We found a previously unidentified gene (flagrante delicto Y, FDY) that originated from a recent duplication of the autosomal gene vig2 to the Y chromosome of Drosophila melanogaster. Four contiguous genes were duplicated along with vig2, but they became pseudogenes through the accumulation of deletions and transposable element insertions, whereas FDY remained functional, acquired testis-specific expression, and now accounts for ∼20% of the vig2-like mRNA in testis. FDY is absent in the closest relatives of D. melanogaster, and DNA sequence divergence indicates that the duplication to the Y chromosome occurred ∼2 million years ago. Thus, FDY provides a snapshot of the early stages of the establishment of a Y-linked gene and demonstrates how the Drosophila Y has been accumulating autosomal genes.

Original languageEnglish (US)
Pages (from-to)12450-12455
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume112
Issue number40
DOIs
StatePublished - Oct 6 2015
Externally publishedYes

Fingerprint

Y-Linked Genes
Drosophila melanogaster
Y Chromosome
Parturition
Drosophila
Genes
Testis
Mammalian Chromosomes
Pseudogenes
Sex Chromosomes
DNA Transposable Elements
Gene Duplication
Chromosomes, Human, Pair 2
X Chromosome
Messenger RNA

Keywords

  • Drosophila melanogaster
  • FDY
  • PacBio
  • Vig2
  • Y chromosome

ASJC Scopus subject areas

  • General

Cite this

Birth of a new gene on the Y chromosome of Drosophila melanogaster. / Carvalho, Antonio Bernardo; Vicoso, Beatriz; Russo, Claudia A M; Swenor, Bonnielin; Clark, Andrew G.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, No. 40, 06.10.2015, p. 12450-12455.

Research output: Contribution to journalArticle

Carvalho, Antonio Bernardo ; Vicoso, Beatriz ; Russo, Claudia A M ; Swenor, Bonnielin ; Clark, Andrew G. / Birth of a new gene on the Y chromosome of Drosophila melanogaster. In: Proceedings of the National Academy of Sciences of the United States of America. 2015 ; Vol. 112, No. 40. pp. 12450-12455.
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