Bipolar disorder ANK3 risk variant effect on sustained attention is replicated in a large healthy population

Alex Hatzimanolis, Nikolaos Smyrnis, Dimitrios Avramopoulos, Costas N. Stefanis, Ioannis Evdokimidis, Nicholas C. Stefanis

Research output: Contribution to journalArticlepeer-review

Abstract

Independent genome-wide association studies have implicated a common single nucleotide polymorphism within the ANK3 gene (rs10994336) in bipolar disorder (BD) susceptibility, thus establishing rs10994336 marker as a strong candidate predisposing genetic factor for BD. Furthermore, recent findings demonstrate that this variant impacts on cognitive functioning in BD patients, their unaffected relatives, and healthy controls by influencing sustained attention. Here, we aimed to replicate this finding in a large population-based sample of healthy young adults (n=1808). Sustained attention was evaluated using the Continuous Performance Test as in the original study and working memory was assessed with the n-back task. Individuals carrying the BD risk T-allele showed significantly reduced sensitivity in target detection, increased errors of commission, and atypical response latency variability. In addition, we confirmed the lack of an association between the rs10994336 variant and working memory, as well as general intellectual ability, suggesting a specific effect on the Continuous Performance Test performance.

Original languageEnglish (US)
Pages (from-to)210-213
Number of pages4
JournalPsychiatric genetics
Volume22
Issue number4
DOIs
StatePublished - Aug 2012

Keywords

  • ANK3
  • CPT-IP
  • ankyrin-G
  • cognition
  • polymorphism
  • sustained attention
  • working memory

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

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