Biphasic activity of resveratrol on indomethacin-induced gastric ulcers

Anindya Dey, Prasun Guha, Subrata Chattopadhyay, Sandip K. Bandyopadhyay

Research output: Contribution to journalArticlepeer-review

Abstract

Resveratrol showed biphasic activity in indomethacin-induced gastric ulcerated mice. A protective effect at a lower dose (2 mg kg-1) and a contraindicative effect at a higher dose of Resveratrol (10 mg kg-1) were observed. This phenomenon was possibly controlled by a COX-1 and eNOS balance, which ultimately maintained angiogenesis in Resveratrol-treated pre-ulcerated mice. The lower dose of Resveratrol (2 mg kg-1) augmented eNOS expression without altering COX-1 expression, but, at a higher dose (10 mg kg-1), Resveratrol predominantly suppressed COX-1 expression, which significantly reduced both PGE2 synthesis and angiogenesis. Thus it ultimately resulted in delay healing of indomethacin-induced gastric ulcers. Hence, it could be concluded that COX-1 and eNOS acted as key regulatory factors switching the biphasic effects of Resveratrol in indomethacin-induced ulcerated mice.

Original languageEnglish (US)
Pages (from-to)90-95
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume381
Issue number1
DOIs
StatePublished - Mar 27 2009
Externally publishedYes

Keywords

  • Angiogenesis
  • COX
  • Gastric ulcer
  • Indomethacin
  • Resveratrol
  • eNOS
  • iNOS

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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