Biphasic activity of resveratrol on indomethacin-induced gastric ulcers

Anindya Dey, Prasun Guha, Subrata Chattopadhyay, Sandip K. Bandyopadhyay

Research output: Contribution to journalArticle

Abstract

Resveratrol showed biphasic activity in indomethacin-induced gastric ulcerated mice. A protective effect at a lower dose (2 mg kg-1) and a contraindicative effect at a higher dose of Resveratrol (10 mg kg-1) were observed. This phenomenon was possibly controlled by a COX-1 and eNOS balance, which ultimately maintained angiogenesis in Resveratrol-treated pre-ulcerated mice. The lower dose of Resveratrol (2 mg kg-1) augmented eNOS expression without altering COX-1 expression, but, at a higher dose (10 mg kg-1), Resveratrol predominantly suppressed COX-1 expression, which significantly reduced both PGE2 synthesis and angiogenesis. Thus it ultimately resulted in delay healing of indomethacin-induced gastric ulcers. Hence, it could be concluded that COX-1 and eNOS acted as key regulatory factors switching the biphasic effects of Resveratrol in indomethacin-induced ulcerated mice.

Original languageEnglish (US)
Pages (from-to)90-95
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume381
Issue number1
DOIs
StatePublished - Mar 27 2009
Externally publishedYes

Fingerprint

Stomach Ulcer
Indomethacin
Dinoprostone
resveratrol
Stomach

Keywords

  • Angiogenesis
  • COX
  • eNOS
  • Gastric ulcer
  • Indomethacin
  • iNOS
  • Resveratrol

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

Biphasic activity of resveratrol on indomethacin-induced gastric ulcers. / Dey, Anindya; Guha, Prasun; Chattopadhyay, Subrata; Bandyopadhyay, Sandip K.

In: Biochemical and Biophysical Research Communications, Vol. 381, No. 1, 27.03.2009, p. 90-95.

Research output: Contribution to journalArticle

Dey, Anindya ; Guha, Prasun ; Chattopadhyay, Subrata ; Bandyopadhyay, Sandip K. / Biphasic activity of resveratrol on indomethacin-induced gastric ulcers. In: Biochemical and Biophysical Research Communications. 2009 ; Vol. 381, No. 1. pp. 90-95.
@article{9a824fe7e59840d1a61c88bb9ac88f03,
title = "Biphasic activity of resveratrol on indomethacin-induced gastric ulcers",
abstract = "Resveratrol showed biphasic activity in indomethacin-induced gastric ulcerated mice. A protective effect at a lower dose (2 mg kg-1) and a contraindicative effect at a higher dose of Resveratrol (10 mg kg-1) were observed. This phenomenon was possibly controlled by a COX-1 and eNOS balance, which ultimately maintained angiogenesis in Resveratrol-treated pre-ulcerated mice. The lower dose of Resveratrol (2 mg kg-1) augmented eNOS expression without altering COX-1 expression, but, at a higher dose (10 mg kg-1), Resveratrol predominantly suppressed COX-1 expression, which significantly reduced both PGE2 synthesis and angiogenesis. Thus it ultimately resulted in delay healing of indomethacin-induced gastric ulcers. Hence, it could be concluded that COX-1 and eNOS acted as key regulatory factors switching the biphasic effects of Resveratrol in indomethacin-induced ulcerated mice.",
keywords = "Angiogenesis, COX, eNOS, Gastric ulcer, Indomethacin, iNOS, Resveratrol",
author = "Anindya Dey and Prasun Guha and Subrata Chattopadhyay and Bandyopadhyay, {Sandip K.}",
year = "2009",
month = "3",
day = "27",
doi = "10.1016/j.bbrc.2009.02.027",
language = "English (US)",
volume = "381",
pages = "90--95",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Biphasic activity of resveratrol on indomethacin-induced gastric ulcers

AU - Dey, Anindya

AU - Guha, Prasun

AU - Chattopadhyay, Subrata

AU - Bandyopadhyay, Sandip K.

PY - 2009/3/27

Y1 - 2009/3/27

N2 - Resveratrol showed biphasic activity in indomethacin-induced gastric ulcerated mice. A protective effect at a lower dose (2 mg kg-1) and a contraindicative effect at a higher dose of Resveratrol (10 mg kg-1) were observed. This phenomenon was possibly controlled by a COX-1 and eNOS balance, which ultimately maintained angiogenesis in Resveratrol-treated pre-ulcerated mice. The lower dose of Resveratrol (2 mg kg-1) augmented eNOS expression without altering COX-1 expression, but, at a higher dose (10 mg kg-1), Resveratrol predominantly suppressed COX-1 expression, which significantly reduced both PGE2 synthesis and angiogenesis. Thus it ultimately resulted in delay healing of indomethacin-induced gastric ulcers. Hence, it could be concluded that COX-1 and eNOS acted as key regulatory factors switching the biphasic effects of Resveratrol in indomethacin-induced ulcerated mice.

AB - Resveratrol showed biphasic activity in indomethacin-induced gastric ulcerated mice. A protective effect at a lower dose (2 mg kg-1) and a contraindicative effect at a higher dose of Resveratrol (10 mg kg-1) were observed. This phenomenon was possibly controlled by a COX-1 and eNOS balance, which ultimately maintained angiogenesis in Resveratrol-treated pre-ulcerated mice. The lower dose of Resveratrol (2 mg kg-1) augmented eNOS expression without altering COX-1 expression, but, at a higher dose (10 mg kg-1), Resveratrol predominantly suppressed COX-1 expression, which significantly reduced both PGE2 synthesis and angiogenesis. Thus it ultimately resulted in delay healing of indomethacin-induced gastric ulcers. Hence, it could be concluded that COX-1 and eNOS acted as key regulatory factors switching the biphasic effects of Resveratrol in indomethacin-induced ulcerated mice.

KW - Angiogenesis

KW - COX

KW - eNOS

KW - Gastric ulcer

KW - Indomethacin

KW - iNOS

KW - Resveratrol

UR - http://www.scopus.com/inward/record.url?scp=61849159299&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=61849159299&partnerID=8YFLogxK

U2 - 10.1016/j.bbrc.2009.02.027

DO - 10.1016/j.bbrc.2009.02.027

M3 - Article

C2 - 19351601

AN - SCOPUS:61849159299

VL - 381

SP - 90

EP - 95

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 1

ER -