Abstract
Resveratrol showed biphasic activity in indomethacin-induced gastric ulcerated mice. A protective effect at a lower dose (2 mg kg-1) and a contraindicative effect at a higher dose of Resveratrol (10 mg kg-1) were observed. This phenomenon was possibly controlled by a COX-1 and eNOS balance, which ultimately maintained angiogenesis in Resveratrol-treated pre-ulcerated mice. The lower dose of Resveratrol (2 mg kg-1) augmented eNOS expression without altering COX-1 expression, but, at a higher dose (10 mg kg-1), Resveratrol predominantly suppressed COX-1 expression, which significantly reduced both PGE2 synthesis and angiogenesis. Thus it ultimately resulted in delay healing of indomethacin-induced gastric ulcers. Hence, it could be concluded that COX-1 and eNOS acted as key regulatory factors switching the biphasic effects of Resveratrol in indomethacin-induced ulcerated mice.
Original language | English (US) |
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Pages (from-to) | 90-95 |
Number of pages | 6 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 381 |
Issue number | 1 |
DOIs | |
State | Published - Mar 27 2009 |
Externally published | Yes |
Keywords
- Angiogenesis
- COX
- Gastric ulcer
- Indomethacin
- Resveratrol
- eNOS
- iNOS
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology