Biosynthesis and roles of phospholipids in mitochondrial fusion, division and mitophagy.

Qiang Zhang, Yasushi Tamura, Madhuparna Roy, Yoshihiro Adachi, Miho Iijima, Hiromi Sesaki

Research output: Contribution to journalReview article

Abstract

Mitochondria move, fuse and divide in cells. The dynamic behavior of mitochondria is central to the control of their structure and function. Three conserved mitochondrial dynamin-related GTPases (i.e., mitofusin, Opa1 and Drp1 in mammals and Fzo1, Mgm1 and Dnm1 in yeast) mediate mitochondrial fusion and division. In addition to dynamins, recent studies demonstrated that phospholipids in mitochondria also play key roles in mitochondrial dynamics by interacting with dynamin GTPases and by directly changing the biophysical properties of the mitochondrial membranes. Changes in phospholipid composition also promote mitophagy, which is a selective mitochondrial degradation process that is mechanistically coupled to mitochondrial division. In this review, we will discuss the biogenesis and function of mitochondrial phospholipids.

Original languageEnglish (US)
Pages (from-to)3767-3778
Number of pages12
JournalCellular and molecular life sciences : CMLS
Volume71
Issue number19
DOIs
StatePublished - Oct 2014

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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