Biophysics of molecular cell mechanics

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cell mechanics controls a wide range of important cell functions, including cell migration, differentiation, polarization, and division. The viscoelastic properties of the nucleus and cytoplasm can be probed with high spatial and temporal resolutions using the method of particle tracking microrheology. In this method, the spontaneous displacements of submicron beads are tracked and rheological parameters, including viscoelastic moduli and creep compliance, are computed from the mean squared displacements. Particle tracking microrheology has revealed changes in cell mechanics associated to wound healing, embryonic development, and human diseases, including laminopathies and cancer.

Original languageEnglish (US)
Title of host publicationComprehensive Biophysics
PublisherElsevier Inc.
Pages104-121
Number of pages18
Volume7
ISBN (Print)9780080957180
DOIs
StatePublished - 2012

Keywords

  • Cell migration
  • Cytoplasm
  • Embryonic development
  • Laminopathies
  • Microrheology
  • Nucleus
  • Submicron beads
  • Viscoelastic properties
  • Wound healing

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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