Biophysics of molecular cell mechanics

D. Wirtz

doi:10.1016/B978-0-12-374920-8.00708-6

Biophysics of molecular cell mechanics

D. Wirtz

Whiting School of Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Cell mechanics controls a wide range of important cell functions, including cell migration, differentiation, polarization, and division. The viscoelastic properties of the nucleus and cytoplasm can be probed with high spatial and temporal resolutions using the method of particle tracking microrheology. In this method, the spontaneous displacements of submicron beads are tracked and rheological parameters, including viscoelastic moduli and creep compliance, are computed from the mean squared displacements. Particle tracking microrheology has revealed changes in cell mechanics associated to wound healing, embryonic development, and human diseases, including laminopathies and cancer.

Original language	English (US)
Title of host publication	Comprehensive Biophysics
Publisher	Elsevier Inc.
Pages	104-121
Number of pages	18
Volume	7
ISBN (Print)	9780080957180
DOIs	https://doi.org/10.1016/B978-0-12-374920-8.00708-6
State	Published - 2012

Keywords

Cell migration
Cytoplasm
Embryonic development
Laminopathies
Microrheology
Nucleus
Submicron beads
Viscoelastic properties
Wound healing

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/B978-0-12-374920-8.00708-6

Cite this

@inbook{8af3af2e2ebb4c1cb5b3df00d6eb306d,

title = "Biophysics of molecular cell mechanics",

abstract = "Cell mechanics controls a wide range of important cell functions, including cell migration, differentiation, polarization, and division. The viscoelastic properties of the nucleus and cytoplasm can be probed with high spatial and temporal resolutions using the method of particle tracking microrheology. In this method, the spontaneous displacements of submicron beads are tracked and rheological parameters, including viscoelastic moduli and creep compliance, are computed from the mean squared displacements. Particle tracking microrheology has revealed changes in cell mechanics associated to wound healing, embryonic development, and human diseases, including laminopathies and cancer.",

keywords = "Cell migration, Cytoplasm, Embryonic development, Laminopathies, Microrheology, Nucleus, Submicron beads, Viscoelastic properties, Wound healing",

author = "D. Wirtz",

note = "Funding Information: The author thanks members of the Wirtz group who developed, tested, and used the method of particle tracking microrheology presented in this chapter. Work in the author's laboratory is supported by the National Institutes of Health grants GM084204 and CA143868.",

year = "2012",

doi = "10.1016/B978-0-12-374920-8.00708-6",

language = "English (US)",

isbn = "9780080957180",

volume = "7",

pages = "104--121",

booktitle = "Comprehensive Biophysics",

publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Biophysics of molecular cell mechanics

AU - Wirtz, D.

N1 - Funding Information: The author thanks members of the Wirtz group who developed, tested, and used the method of particle tracking microrheology presented in this chapter. Work in the author's laboratory is supported by the National Institutes of Health grants GM084204 and CA143868.

PY - 2012

Y1 - 2012

N2 - Cell mechanics controls a wide range of important cell functions, including cell migration, differentiation, polarization, and division. The viscoelastic properties of the nucleus and cytoplasm can be probed with high spatial and temporal resolutions using the method of particle tracking microrheology. In this method, the spontaneous displacements of submicron beads are tracked and rheological parameters, including viscoelastic moduli and creep compliance, are computed from the mean squared displacements. Particle tracking microrheology has revealed changes in cell mechanics associated to wound healing, embryonic development, and human diseases, including laminopathies and cancer.

AB - Cell mechanics controls a wide range of important cell functions, including cell migration, differentiation, polarization, and division. The viscoelastic properties of the nucleus and cytoplasm can be probed with high spatial and temporal resolutions using the method of particle tracking microrheology. In this method, the spontaneous displacements of submicron beads are tracked and rheological parameters, including viscoelastic moduli and creep compliance, are computed from the mean squared displacements. Particle tracking microrheology has revealed changes in cell mechanics associated to wound healing, embryonic development, and human diseases, including laminopathies and cancer.

KW - Cell migration

KW - Cytoplasm

KW - Embryonic development

KW - Laminopathies

KW - Microrheology

KW - Nucleus

KW - Submicron beads

KW - Viscoelastic properties

KW - Wound healing

UR - http://www.scopus.com/inward/record.url?scp=84882801508&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882801508&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-374920-8.00708-6

DO - 10.1016/B978-0-12-374920-8.00708-6

M3 - Chapter

AN - SCOPUS:84882801508

SN - 9780080957180

VL - 7

SP - 104

EP - 121

BT - Comprehensive Biophysics

PB - Elsevier Inc.

ER -

Biophysics of molecular cell mechanics

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this