Biophysics and physiology of cardiac calcium channels

C. W. Balke, W. C. Rose, B. O'Rourke, R. Mejia-Alvarez, P. Backx, E. Marban

Research output: Contribution to journalReview article

Abstract

Two types of calcium channels are present in heart cells; the two types, L and T, can be clearly distinguished on the basis of their biophysical and pharmacological properties. The physiological role of L-type Ca2+ channels is clear and includes mediation of processes that are vital to the function of normal cardiac cells, such as electrical conduction and excitation- contraction coupling. The physiological role of T-channels is not known, although potential involvement in pacemaker activity can be hypothesized on the basis of their biophysical properties. The testing of these predictions is the subject of intense research interest at present.

Original languageEnglish (US)
Pages (from-to)VII49-VII53
JournalCirculation
Volume87
Issue number6 SUPPL. VII
StatePublished - Jun 21 1993

Keywords

  • calcium channels

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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  • Cite this

    Balke, C. W., Rose, W. C., O'Rourke, B., Mejia-Alvarez, R., Backx, P., & Marban, E. (1993). Biophysics and physiology of cardiac calcium channels. Circulation, 87(6 SUPPL. VII), VII49-VII53.