Bioorthogonal chemistry for 68Ga radiolabelling of DOTA-containing compounds

Helen L. Evans, Laurence Carroll, Eric O. Aboagye, Alan C. Spivey

Research output: Contribution to journalArticle

Abstract

Copper-catalysed 'click' chemistry is a highly utilised technique for radiolabelling small molecules and peptides for imaging applications. The usefulness of these reactions falls short, however, when metal catalysis is not a practically viable route; such as when using metal chelates as radioligands. Here, we describe a method for carrying out 'click-type' radiochemistry in the presence of DOTA chelates, by combining 68Ga radiolabelling techniques with well-established bioorthogonal reactions, which do not rely upon metal catalysis.

Original languageEnglish (US)
Pages (from-to)291-297
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume57
Issue number4
DOIs
Publication statusPublished - Jan 1 2014
Externally publishedYes

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Keywords

  • azide
  • Bioorthogonal chemistry
  • click chemistry
  • cyclooctyne
  • DOTA
  • Gallium-68
  • norbornene
  • strained alkene
  • tetrazine

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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