Biomonitoring of United States Army soldiers serving in Kuwait in 1991

Miriam C. Poirier, Ainsley Weston, Bernadette Schoket, Hanadi Shamkhani, Ching Fei Pan, Melissa A. McDiarmid, Brian G. Scott, David P. Deeter, Jack M. Heller, David Jacobson-Kram, Nathaniel Rothman

Research output: Contribution to journalArticle

Abstract

Biomarkers of polycyclic aromatic hydrocarbon (PAH) exposure and genetic biomarkers of potential cancer susceptibility were determined in a group of United States Army soldiers who were deployed to Kuwait and Saudi Arabia in 1991 in the aftermath of the Persian Gulf War. Because hundreds of oil well fires were still burning, there was concern that ground troops stationed in Kuwait might be exposed to high levels of PAHs and other toxicants. The United States Army Environmental Hygiene Agency monitored air and soil for ambient PAHs. In addition, a group of 61 soldiers was involved in the biomonitoring study reported here. These soldiers kept diaries of daily activities and provided blood and urine samples in Germany (June) before deployment to Kuwait, after 8 weeks in Kuwait (August), and 1 month after the return to Germany (October). Here we present data for PAH-DNA adducts measured by immunoassay in blood cell DNA samples obtained at all three sampling times from 22 soldiers and bulky aromatic adducts measured by 32P- postlabeling in blood cell DNA samples from 20 of the same soldiers. Urinary 1-hydroxypyrene-glucuronide levels were determined by synchronous fluorescence spectrometry in a matched set of samples from 33 soldiers. Contrary to expectations, environmental monitoring showed low ambient PAH levels in the areas where these soldiers were working in Kuwait. For both DNA adduct assays, levels were the lowest in Kuwait in August and increased significantly after the soldiers returned to Germany (October). Urinary 1- hydroxypyrene-glucuronide levels were also lowest in Kuwait and highest in Germany, but the differences were not statistically significant. The PAH- exposure biomarker levels were not significantly influenced by polymorphic variations of CYP1A1 (MspI) and glutathione S-transferases M1 and T1. Overall, the data suggest that this group of soldiers was not exposed to elevated levels of PAHs while deployed in Kuwait.

Original languageEnglish (US)
Pages (from-to)545-551
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume7
Issue number6
StatePublished - Jun 1998
Externally publishedYes

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Kuwait
Environmental Monitoring
Military Personnel
Germany
Polycyclic Aromatic Hydrocarbons
Blood Cells
Biomarkers
Oil and Gas Fields
Indian Ocean
Cytochrome P-450 CYP1A1
DNA Adducts
Saudi Arabia
DNA
Fluorescence Spectrometry
Tumor Biomarkers
Hygiene
Immunoassay
Soil
Air
Urine

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Poirier, M. C., Weston, A., Schoket, B., Shamkhani, H., Pan, C. F., McDiarmid, M. A., ... Rothman, N. (1998). Biomonitoring of United States Army soldiers serving in Kuwait in 1991. Cancer Epidemiology Biomarkers and Prevention, 7(6), 545-551.

Biomonitoring of United States Army soldiers serving in Kuwait in 1991. / Poirier, Miriam C.; Weston, Ainsley; Schoket, Bernadette; Shamkhani, Hanadi; Pan, Ching Fei; McDiarmid, Melissa A.; Scott, Brian G.; Deeter, David P.; Heller, Jack M.; Jacobson-Kram, David; Rothman, Nathaniel.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 7, No. 6, 06.1998, p. 545-551.

Research output: Contribution to journalArticle

Poirier, MC, Weston, A, Schoket, B, Shamkhani, H, Pan, CF, McDiarmid, MA, Scott, BG, Deeter, DP, Heller, JM, Jacobson-Kram, D & Rothman, N 1998, 'Biomonitoring of United States Army soldiers serving in Kuwait in 1991', Cancer Epidemiology Biomarkers and Prevention, vol. 7, no. 6, pp. 545-551.
Poirier MC, Weston A, Schoket B, Shamkhani H, Pan CF, McDiarmid MA et al. Biomonitoring of United States Army soldiers serving in Kuwait in 1991. Cancer Epidemiology Biomarkers and Prevention. 1998 Jun;7(6):545-551.
Poirier, Miriam C. ; Weston, Ainsley ; Schoket, Bernadette ; Shamkhani, Hanadi ; Pan, Ching Fei ; McDiarmid, Melissa A. ; Scott, Brian G. ; Deeter, David P. ; Heller, Jack M. ; Jacobson-Kram, David ; Rothman, Nathaniel. / Biomonitoring of United States Army soldiers serving in Kuwait in 1991. In: Cancer Epidemiology Biomarkers and Prevention. 1998 ; Vol. 7, No. 6. pp. 545-551.
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