TY - JOUR
T1 - Biomonitoring of lead, cadmium, total mercury, and methylmercury levels in maternal blood and in umbilical cord blood at birth in South Korea
AU - Kim, Yu Mi
AU - Chung, Jin Young
AU - An, Hyun Sook
AU - Park, Sung Yong
AU - Kim, Byoung Gwon
AU - Bae, Jong Woon
AU - Han, Myoungseok
AU - Cho, Yeon Jean
AU - Hong, Young Seoub
N1 - Publisher Copyright:
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
PY - 2015/10/26
Y1 - 2015/10/26
N2 - With rising concerns of heavy metal exposure in pregnancy and early childhood, this study was conducted to assess the relationship between the lead, cadmium, mercury, and methylmercury blood levels in pregnancy and neonatal period. The study population included 104 mothers and their children pairs who completed both baseline maternal blood sampling at the second trimester and umbilical cord blood sampling at birth. The geometric mean maternal blood levels of lead, cadmium, total mercury, and methylmercury at the second trimester were 1.02 ± 1.39 μg/dL, 0.61 ± 1.51 μg/L, 2.97 ± 1.45 μg/L, and 2.39 ± 1.45 μg/L, respectively, and in the newborns, these levels at birth were 0.71 ± 1.42 μg/dL, 0.01 ± 5.31 μg/L, 4.44 ± 1.49 μg/L, and 3.67 ± 1.51 μg/L, respectively. The mean ratios of lead, cadmium, total mercury, and methylmercury levels in the newborns to those in the mothers were 0.72, 0.04, 1.76, and 1.81, respectively. The levels of most heavy metals in pregnant women and infants were higher in this study than in studies from industrialized western countries. The placenta appears to protect fetuses from cadmium; however, total mercury and methylmercury were able to cross the placenta and accumulate in fetuses.
AB - With rising concerns of heavy metal exposure in pregnancy and early childhood, this study was conducted to assess the relationship between the lead, cadmium, mercury, and methylmercury blood levels in pregnancy and neonatal period. The study population included 104 mothers and their children pairs who completed both baseline maternal blood sampling at the second trimester and umbilical cord blood sampling at birth. The geometric mean maternal blood levels of lead, cadmium, total mercury, and methylmercury at the second trimester were 1.02 ± 1.39 μg/dL, 0.61 ± 1.51 μg/L, 2.97 ± 1.45 μg/L, and 2.39 ± 1.45 μg/L, respectively, and in the newborns, these levels at birth were 0.71 ± 1.42 μg/dL, 0.01 ± 5.31 μg/L, 4.44 ± 1.49 μg/L, and 3.67 ± 1.51 μg/L, respectively. The mean ratios of lead, cadmium, total mercury, and methylmercury levels in the newborns to those in the mothers were 0.72, 0.04, 1.76, and 1.81, respectively. The levels of most heavy metals in pregnant women and infants were higher in this study than in studies from industrialized western countries. The placenta appears to protect fetuses from cadmium; however, total mercury and methylmercury were able to cross the placenta and accumulate in fetuses.
KW - Biomonitoring
KW - Cadmium
KW - Heavy metals
KW - Lead
KW - Mercury
KW - Methylmercury
KW - Pregnancy
KW - Umbilical cord
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U2 - 10.3390/ijerph121013482
DO - 10.3390/ijerph121013482
M3 - Article
C2 - 26516876
AN - SCOPUS:84945411693
SN - 1661-7827
VL - 12
SP - 13482
EP - 13493
JO - International journal of environmental research and public health
JF - International journal of environmental research and public health
IS - 10
ER -