Biomolecule delivery to engineer the cellular microenvironment for regenerative medicine

Corey J. Bishop, Jayoung Kim, Jordan J. Green

Research output: Contribution to journalArticle

Abstract

To realize the potential of regenerative medicine, controlling the delivery of biomolecules in the cellular microenvironment is important as these factors control cell fate. Controlled delivery for tissue engineering and regenerative medicine often requires bioengineered materials and cells capable of spatiotemporal modulation of biomolecule release and presentation. This review discusses biomolecule delivery from the outside of the cell inwards through the delivery of soluble and insoluble biomolecules as well as from the inside of the cell outwards through gene transfer. Ex vivo and in vivo therapeutic strategies are discussed, as well as combination delivery of biomolecules, scaffolds, and cells. Various applications in regenerative medicine are highlighted including bone tissue engineering and wound healing.

Original languageEnglish (US)
Pages (from-to)1557-1572
Number of pages16
JournalAnnals of biomedical engineering
Volume42
Issue number7
DOIs
StatePublished - Jul 2014

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Keywords

  • Biomaterial
  • Cell therapy
  • Controlled drug delivery
  • Gene delivery
  • Tissue engineering

ASJC Scopus subject areas

  • Biomedical Engineering

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