Biomolecule delivery to engineer the cellular microenvironment for regenerative medicine

Corey J. Bishop; Jayoung Kim; Jordan J. Green

doi:10.1007/s10439-013-0932-1

Biomolecule delivery to engineer the cellular microenvironment for regenerative medicine

Corey J. Bishop, Jayoung Kim, Jordan J. Green

School of Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

To realize the potential of regenerative medicine, controlling the delivery of biomolecules in the cellular microenvironment is important as these factors control cell fate. Controlled delivery for tissue engineering and regenerative medicine often requires bioengineered materials and cells capable of spatiotemporal modulation of biomolecule release and presentation. This review discusses biomolecule delivery from the outside of the cell inwards through the delivery of soluble and insoluble biomolecules as well as from the inside of the cell outwards through gene transfer. Ex vivo and in vivo therapeutic strategies are discussed, as well as combination delivery of biomolecules, scaffolds, and cells. Various applications in regenerative medicine are highlighted including bone tissue engineering and wound healing.

Original language	English (US)
Pages (from-to)	1557-1572
Number of pages	16
Journal	Annals of biomedical engineering
Volume	42
Issue number	7
DOIs	https://doi.org/10.1007/s10439-013-0932-1
State	Published - Jul 2014

Keywords

Biomaterial
Cell therapy
Controlled drug delivery
Gene delivery
Tissue engineering

ASJC Scopus subject areas

Biomedical Engineering

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10.1007/s10439-013-0932-1

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title = "Biomolecule delivery to engineer the cellular microenvironment for regenerative medicine",

abstract = "To realize the potential of regenerative medicine, controlling the delivery of biomolecules in the cellular microenvironment is important as these factors control cell fate. Controlled delivery for tissue engineering and regenerative medicine often requires bioengineered materials and cells capable of spatiotemporal modulation of biomolecule release and presentation. This review discusses biomolecule delivery from the outside of the cell inwards through the delivery of soluble and insoluble biomolecules as well as from the inside of the cell outwards through gene transfer. Ex vivo and in vivo therapeutic strategies are discussed, as well as combination delivery of biomolecules, scaffolds, and cells. Various applications in regenerative medicine are highlighted including bone tissue engineering and wound healing.",

keywords = "Biomaterial, Cell therapy, Controlled drug delivery, Gene delivery, Tissue engineering",

author = "Bishop, {Corey J.} and Jayoung Kim and Green, {Jordan J.}",

note = "Funding Information: NSF GRF: DGE-0707427 to CJB and Samsung Scholarship to JK. This work was also supported in part by the National Institutes of Health (R01EB016721-01 and R21CA152473).",

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AU - Kim, Jayoung

AU - Green, Jordan J.

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AB - To realize the potential of regenerative medicine, controlling the delivery of biomolecules in the cellular microenvironment is important as these factors control cell fate. Controlled delivery for tissue engineering and regenerative medicine often requires bioengineered materials and cells capable of spatiotemporal modulation of biomolecule release and presentation. This review discusses biomolecule delivery from the outside of the cell inwards through the delivery of soluble and insoluble biomolecules as well as from the inside of the cell outwards through gene transfer. Ex vivo and in vivo therapeutic strategies are discussed, as well as combination delivery of biomolecules, scaffolds, and cells. Various applications in regenerative medicine are highlighted including bone tissue engineering and wound healing.

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Biomolecule delivery to engineer the cellular microenvironment for regenerative medicine

Abstract

Keywords

ASJC Scopus subject areas

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