Biomimetics of the extracellular matrix: An integrated three-dimensional fiber-hydrogel composite for cartilage tissue engineering

Jeannine Coburn, Matt Gibson, Pierre Alain Bandalini, Christopher Laird, Hai Quan Mao, Lorenzo Moroni, Dror Seliktar, Jennifer Elisseeff

Research output: Contribution to journalArticle

Abstract

The native extracellular matrix (ECM) consists of an integrated fibrous protein network and proteoglycan-based ground (hydrogel) substance. We designed a novel electrospinning technique to engineer a three dimensional fiber-hydrogel composite that mimics the native ECM structure, is injectable, and has practical macroscale dimensions for clinically relevant tissue defects. In a model system of articular cartilage tissue engineering, the fiber-hydrogel composites enhanced the biological response of adult stem cells, with dynamic mechanical stimulation resulting in near native levels of extracellular matrix. This technology platform was expanded through structural and biochemical modification of the fibers including hydrophilic fibers containing chondroitin sulfate, a significant component of endogenous tissues, and hydrophobic fibers containing ECM microparticles.

Original languageEnglish (US)
Pages (from-to)213-222
Number of pages10
JournalSmart Structures and Systems
Volume7
Issue number3
DOIs
StatePublished - Mar 2011

Keywords

  • Biomimetic
  • Cartilage
  • Electrospin
  • Extracellular matrix
  • Fibers
  • Hydrogel
  • Tissue engineering

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Computer Science Applications
  • Electrical and Electronic Engineering

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