Biomimetic polydopamine coating on gold nanorods for biofunctionalization, imaging, and photothermal therapy

Kvar C.L. Black, Ji Yi, José G. Rivera, Daria C. Zelasko-Leon, Phillip B. Messersmith

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A biomimetic polydopamine (PD)-based strategy was employed for presenting antibodies on gold nanorods (NRs) to target cancer cells for photothermal therapy. PD was polymerized onto NRs, and epidermal growth factor receptor antibodies (anti-EGFR) were immobilized onto the layer. Anti-EGFR-PD-NRs specifically bound to EGFRoverexpressing cells as quantified by optical coherence tomography, and illumination enhanced cell death compared to non-irradiated or antibody-free controls.

Original languageEnglish (US)
Title of host publicationBioinspired, Biointegrated, Bioengineered Photonic Devices
DOIs
StatePublished - 2013
Externally publishedYes
EventBioinspired, Biointegrated, Bioengineered Photonic Devices - San Francisco, CA, United States
Duration: Feb 2 2013Feb 3 2013

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8598
ISSN (Print)1605-7422

Conference

ConferenceBioinspired, Biointegrated, Bioengineered Photonic Devices
CountryUnited States
CitySan Francisco, CA
Period2/2/132/3/13

Keywords

  • cancer
  • catecholamine
  • mussel adhesive proteins
  • optical imaging
  • photothermal therapy
  • plasmonic nanoparticles
  • polydopamine
  • surface plasmon resonance

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Biomimetic polydopamine coating on gold nanorods for biofunctionalization, imaging, and photothermal therapy'. Together they form a unique fingerprint.

Cite this