Biomimetic polydopamine coating on gold nanorods for biofunctionalization, imaging, and photothermal therapy

Kvar C.L. Black; Ji Yi; José G. Rivera; Daria C. Zelasko-Leon; Phillip B. Messersmith

doi:10.1117/12.2005041

Biomimetic polydopamine coating on gold nanorods for biofunctionalization, imaging, and photothermal therapy

Kvar C.L. Black, Ji Yi, José G. Rivera, Daria C. Zelasko-Leon, Phillip B. Messersmith

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

A biomimetic polydopamine (PD)-based strategy was employed for presenting antibodies on gold nanorods (NRs) to target cancer cells for photothermal therapy. PD was polymerized onto NRs, and epidermal growth factor receptor antibodies (anti-EGFR) were immobilized onto the layer. Anti-EGFR-PD-NRs specifically bound to EGFRoverexpressing cells as quantified by optical coherence tomography, and illumination enhanced cell death compared to non-irradiated or antibody-free controls.

Original language	English (US)
Title of host publication	Bioinspired, Biointegrated, Bioengineered Photonic Devices
DOIs	https://doi.org/10.1117/12.2005041
State	Published - 2013
Externally published	Yes
Event	Bioinspired, Biointegrated, Bioengineered Photonic Devices - San Francisco, CA, United States Duration: Feb 2 2013 → Feb 3 2013

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	8598
ISSN (Print)	1605-7422

Conference

Conference	Bioinspired, Biointegrated, Bioengineered Photonic Devices
Country/Territory	United States
City	San Francisco, CA
Period	2/2/13 → 2/3/13

Keywords

cancer
catecholamine
mussel adhesive proteins
optical imaging
photothermal therapy
plasmonic nanoparticles
polydopamine
surface plasmon resonance

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging
Biomaterials

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10.1117/12.2005041

Cite this

Black, K. C. L., Yi, J., Rivera, J. G., Zelasko-Leon, D. C., & Messersmith, P. B. (2013). Biomimetic polydopamine coating on gold nanorods for biofunctionalization, imaging, and photothermal therapy. In Bioinspired, Biointegrated, Bioengineered Photonic Devices Article 85980D (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8598). https://doi.org/10.1117/12.2005041

Biomimetic polydopamine coating on gold nanorods for biofunctionalization, imaging, and photothermal therapy. / Black, Kvar C.L.; Yi, Ji; Rivera, José G. et al.
Bioinspired, Biointegrated, Bioengineered Photonic Devices. 2013. 85980D (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8598).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Black, KCL, Yi, J, Rivera, JG, Zelasko-Leon, DC & Messersmith, PB 2013, Biomimetic polydopamine coating on gold nanorods for biofunctionalization, imaging, and photothermal therapy. in Bioinspired, Biointegrated, Bioengineered Photonic Devices., 85980D, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 8598, Bioinspired, Biointegrated, Bioengineered Photonic Devices, San Francisco, CA, United States, 2/2/13. https://doi.org/10.1117/12.2005041

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title = "Biomimetic polydopamine coating on gold nanorods for biofunctionalization, imaging, and photothermal therapy",

abstract = "A biomimetic polydopamine (PD)-based strategy was employed for presenting antibodies on gold nanorods (NRs) to target cancer cells for photothermal therapy. PD was polymerized onto NRs, and epidermal growth factor receptor antibodies (anti-EGFR) were immobilized onto the layer. Anti-EGFR-PD-NRs specifically bound to EGFRoverexpressing cells as quantified by optical coherence tomography, and illumination enhanced cell death compared to non-irradiated or antibody-free controls.",

keywords = "cancer, catecholamine, mussel adhesive proteins, optical imaging, photothermal therapy, plasmonic nanoparticles, polydopamine, surface plasmon resonance",

author = "Black, {Kvar C.L.} and Ji Yi and Rivera, {Jos{\'e} G.} and Zelasko-Leon, {Daria C.} and Messersmith, {Phillip B.}",

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AU - Rivera, José G.

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AU - Messersmith, Phillip B.

PY - 2013

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N2 - A biomimetic polydopamine (PD)-based strategy was employed for presenting antibodies on gold nanorods (NRs) to target cancer cells for photothermal therapy. PD was polymerized onto NRs, and epidermal growth factor receptor antibodies (anti-EGFR) were immobilized onto the layer. Anti-EGFR-PD-NRs specifically bound to EGFRoverexpressing cells as quantified by optical coherence tomography, and illumination enhanced cell death compared to non-irradiated or antibody-free controls.

AB - A biomimetic polydopamine (PD)-based strategy was employed for presenting antibodies on gold nanorods (NRs) to target cancer cells for photothermal therapy. PD was polymerized onto NRs, and epidermal growth factor receptor antibodies (anti-EGFR) were immobilized onto the layer. Anti-EGFR-PD-NRs specifically bound to EGFRoverexpressing cells as quantified by optical coherence tomography, and illumination enhanced cell death compared to non-irradiated or antibody-free controls.

KW - cancer

KW - catecholamine

KW - mussel adhesive proteins

KW - optical imaging

KW - photothermal therapy

KW - plasmonic nanoparticles

KW - polydopamine

KW - surface plasmon resonance

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Biomimetic polydopamine coating on gold nanorods for biofunctionalization, imaging, and photothermal therapy

Abstract

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Conference

Keywords

ASJC Scopus subject areas

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