Biomimetic particles as therapeutics

Randall A. Meyer; Joel C. Sunshine; Jordan J. Green

doi:10.1016/j.tibtech.2015.07.001

Biomimetic particles as therapeutics

Randall A. Meyer, Joel C. Sunshine, Jordan J. Green

School of Medicine

Research output: Contribution to journal › Review article › peer-review

62 Scopus citations

Abstract

In recent years, there have been major advances in the development of novel nanoparticle- and microparticle-based therapeutics. An emerging paradigm is the incorporation of biomimetic features into these synthetic therapeutic constructs to enable them to better interface with biological systems. Through the control of size, shape, and material consistency, particle cores have been generated that better mimic natural cells and viruses. In addition, there have been significant advances in biomimetic surface functionalization of particles through the integration of bio-inspired artificial cell membranes and naturally derived cell membranes. Biomimetic technologies enable therapeutic particles to have increased potency to benefit human health.

Original language	English (US)
Pages (from-to)	514-524
Number of pages	11
Journal	Trends in Biotechnology
Volume	33
Issue number	9
DOIs	https://doi.org/10.1016/j.tibtech.2015.07.001
State	Published - Sep 1 2015

Keywords

Biomaterial
Biomimetic
Drug delivery
Micro/nanoparticle

ASJC Scopus subject areas

Biotechnology
Bioengineering

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10.1016/j.tibtech.2015.07.001

Cite this

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title = "Biomimetic particles as therapeutics",

abstract = "In recent years, there have been major advances in the development of novel nanoparticle- and microparticle-based therapeutics. An emerging paradigm is the incorporation of biomimetic features into these synthetic therapeutic constructs to enable them to better interface with biological systems. Through the control of size, shape, and material consistency, particle cores have been generated that better mimic natural cells and viruses. In addition, there have been significant advances in biomimetic surface functionalization of particles through the integration of bio-inspired artificial cell membranes and naturally derived cell membranes. Biomimetic technologies enable therapeutic particles to have increased potency to benefit human health.",

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AU - Meyer, Randall A.

AU - Sunshine, Joel C.

AU - Green, Jordan J.

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N2 - In recent years, there have been major advances in the development of novel nanoparticle- and microparticle-based therapeutics. An emerging paradigm is the incorporation of biomimetic features into these synthetic therapeutic constructs to enable them to better interface with biological systems. Through the control of size, shape, and material consistency, particle cores have been generated that better mimic natural cells and viruses. In addition, there have been significant advances in biomimetic surface functionalization of particles through the integration of bio-inspired artificial cell membranes and naturally derived cell membranes. Biomimetic technologies enable therapeutic particles to have increased potency to benefit human health.

AB - In recent years, there have been major advances in the development of novel nanoparticle- and microparticle-based therapeutics. An emerging paradigm is the incorporation of biomimetic features into these synthetic therapeutic constructs to enable them to better interface with biological systems. Through the control of size, shape, and material consistency, particle cores have been generated that better mimic natural cells and viruses. In addition, there have been significant advances in biomimetic surface functionalization of particles through the integration of bio-inspired artificial cell membranes and naturally derived cell membranes. Biomimetic technologies enable therapeutic particles to have increased potency to benefit human health.

KW - Biomaterial

KW - Biomimetic

KW - Drug delivery

KW - Micro/nanoparticle

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VL - 33

SP - 514

EP - 524

JO - Trends in Biotechnology

JF - Trends in Biotechnology

IS - 9

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Biomimetic particles as therapeutics

Abstract

Keywords

ASJC Scopus subject areas

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