Biomimetic particles as therapeutics

Randall A. Meyer, Joel C. Sunshine, Jordan J. Green

Research output: Contribution to journalReview article

Abstract

In recent years, there have been major advances in the development of novel nanoparticle- and microparticle-based therapeutics. An emerging paradigm is the incorporation of biomimetic features into these synthetic therapeutic constructs to enable them to better interface with biological systems. Through the control of size, shape, and material consistency, particle cores have been generated that better mimic natural cells and viruses. In addition, there have been significant advances in biomimetic surface functionalization of particles through the integration of bio-inspired artificial cell membranes and naturally derived cell membranes. Biomimetic technologies enable therapeutic particles to have increased potency to benefit human health.

Original languageEnglish (US)
Pages (from-to)514-524
Number of pages11
JournalTrends in Biotechnology
Volume33
Issue number9
DOIs
StatePublished - Sep 1 2015

Keywords

  • Biomaterial
  • Biomimetic
  • Drug delivery
  • Micro/nanoparticle

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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