Biomimetic approach to tissue engineering

Warren L. Grayson, Timothy P. Martens, George M. Eng, Milica Radisic, Gordana Vunjak-Novakovic

Research output: Contribution to journalReview articlepeer-review

Abstract

The overall goal of tissue engineering is to create functional tissue grafts that can regenerate or replace our defective or worn out tissues and organs. Examples of grafts that are now in pre-clinical studies or clinical use include engineered skin, cartilage, bone, blood vessels, skeletal muscle, bladder, trachea, and myocardium. Engineered tissues are also finding applications as platforms for pharmacological and physiological studies in vitro. To fully mobilize the cell's biological potential, a new generation of tissue engineering systems is now being developed to more closely recapitulate the native developmental milieu, and mimic the physiologic mechanisms of transport and signaling. We discuss the interactions between regenerative biology and engineering, in the context of (i) creation of functional tissue grafts for regenerative medicine (where biological input is critical), and (ii) studies of stem cells, development and disease (where engineered tissues can serve as advanced 3D models).

Original languageEnglish (US)
Pages (from-to)665-673
Number of pages9
JournalSeminars in Cell and Developmental Biology
Volume20
Issue number6
DOIs
StatePublished - Aug 2009
Externally publishedYes

Keywords

  • Bioreactor
  • Electrical signals
  • Perfusion
  • Scaffold
  • Stem cells

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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