TY - JOUR
T1 - Biomimetic approach to tissue engineering
AU - Grayson, Warren L.
AU - Martens, Timothy P.
AU - Eng, George M.
AU - Radisic, Milica
AU - Vunjak-Novakovic, Gordana
N1 - Funding Information:
The authors gratefully acknowledge research support by the National Institutes of Health (HL076485, DE16525 and EB002520 to G.V.-N.) and Canada Foundation for Innovation (Leaders Opportunity Fund to M.R.).
PY - 2009/8
Y1 - 2009/8
N2 - The overall goal of tissue engineering is to create functional tissue grafts that can regenerate or replace our defective or worn out tissues and organs. Examples of grafts that are now in pre-clinical studies or clinical use include engineered skin, cartilage, bone, blood vessels, skeletal muscle, bladder, trachea, and myocardium. Engineered tissues are also finding applications as platforms for pharmacological and physiological studies in vitro. To fully mobilize the cell's biological potential, a new generation of tissue engineering systems is now being developed to more closely recapitulate the native developmental milieu, and mimic the physiologic mechanisms of transport and signaling. We discuss the interactions between regenerative biology and engineering, in the context of (i) creation of functional tissue grafts for regenerative medicine (where biological input is critical), and (ii) studies of stem cells, development and disease (where engineered tissues can serve as advanced 3D models).
AB - The overall goal of tissue engineering is to create functional tissue grafts that can regenerate or replace our defective or worn out tissues and organs. Examples of grafts that are now in pre-clinical studies or clinical use include engineered skin, cartilage, bone, blood vessels, skeletal muscle, bladder, trachea, and myocardium. Engineered tissues are also finding applications as platforms for pharmacological and physiological studies in vitro. To fully mobilize the cell's biological potential, a new generation of tissue engineering systems is now being developed to more closely recapitulate the native developmental milieu, and mimic the physiologic mechanisms of transport and signaling. We discuss the interactions between regenerative biology and engineering, in the context of (i) creation of functional tissue grafts for regenerative medicine (where biological input is critical), and (ii) studies of stem cells, development and disease (where engineered tissues can serve as advanced 3D models).
KW - Bioreactor
KW - Electrical signals
KW - Perfusion
KW - Scaffold
KW - Stem cells
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U2 - 10.1016/j.semcdb.2008.12.008
DO - 10.1016/j.semcdb.2008.12.008
M3 - Review article
C2 - 19146967
AN - SCOPUS:67649454432
SN - 1084-9521
VL - 20
SP - 665
EP - 673
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
IS - 6
ER -