Biomimetic approach to tissue engineering

Warren L Grayson, Timothy P. Martens, George M. Eng, Milica Radisic, Gordana Vunjak-Novakovic

Research output: Contribution to journalArticle

Abstract

The overall goal of tissue engineering is to create functional tissue grafts that can regenerate or replace our defective or worn out tissues and organs. Examples of grafts that are now in pre-clinical studies or clinical use include engineered skin, cartilage, bone, blood vessels, skeletal muscle, bladder, trachea, and myocardium. Engineered tissues are also finding applications as platforms for pharmacological and physiological studies in vitro. To fully mobilize the cell's biological potential, a new generation of tissue engineering systems is now being developed to more closely recapitulate the native developmental milieu, and mimic the physiologic mechanisms of transport and signaling. We discuss the interactions between regenerative biology and engineering, in the context of (i) creation of functional tissue grafts for regenerative medicine (where biological input is critical), and (ii) studies of stem cells, development and disease (where engineered tissues can serve as advanced 3D models).

Original languageEnglish (US)
Pages (from-to)665-673
Number of pages9
JournalSeminars in Cell and Developmental Biology
Volume20
Issue number6
DOIs
StatePublished - Aug 2009
Externally publishedYes

Fingerprint

Biomimetics
Tissue Engineering
Transplants
Regenerative Medicine
Trachea
Cartilage
Blood Vessels
Myocardium
Skeletal Muscle
Urinary Bladder
Stem Cells
Pharmacology
Bone and Bones
Skin

Keywords

  • Bioreactor
  • Electrical signals
  • Perfusion
  • Scaffold
  • Stem cells

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Grayson, W. L., Martens, T. P., Eng, G. M., Radisic, M., & Vunjak-Novakovic, G. (2009). Biomimetic approach to tissue engineering. Seminars in Cell and Developmental Biology, 20(6), 665-673. https://doi.org/10.1016/j.semcdb.2008.12.008

Biomimetic approach to tissue engineering. / Grayson, Warren L; Martens, Timothy P.; Eng, George M.; Radisic, Milica; Vunjak-Novakovic, Gordana.

In: Seminars in Cell and Developmental Biology, Vol. 20, No. 6, 08.2009, p. 665-673.

Research output: Contribution to journalArticle

Grayson, WL, Martens, TP, Eng, GM, Radisic, M & Vunjak-Novakovic, G 2009, 'Biomimetic approach to tissue engineering', Seminars in Cell and Developmental Biology, vol. 20, no. 6, pp. 665-673. https://doi.org/10.1016/j.semcdb.2008.12.008
Grayson, Warren L ; Martens, Timothy P. ; Eng, George M. ; Radisic, Milica ; Vunjak-Novakovic, Gordana. / Biomimetic approach to tissue engineering. In: Seminars in Cell and Developmental Biology. 2009 ; Vol. 20, No. 6. pp. 665-673.
@article{0c0631b047064e1d841d8c33a0b6e0c1,
title = "Biomimetic approach to tissue engineering",
abstract = "The overall goal of tissue engineering is to create functional tissue grafts that can regenerate or replace our defective or worn out tissues and organs. Examples of grafts that are now in pre-clinical studies or clinical use include engineered skin, cartilage, bone, blood vessels, skeletal muscle, bladder, trachea, and myocardium. Engineered tissues are also finding applications as platforms for pharmacological and physiological studies in vitro. To fully mobilize the cell's biological potential, a new generation of tissue engineering systems is now being developed to more closely recapitulate the native developmental milieu, and mimic the physiologic mechanisms of transport and signaling. We discuss the interactions between regenerative biology and engineering, in the context of (i) creation of functional tissue grafts for regenerative medicine (where biological input is critical), and (ii) studies of stem cells, development and disease (where engineered tissues can serve as advanced 3D models).",
keywords = "Bioreactor, Electrical signals, Perfusion, Scaffold, Stem cells",
author = "Grayson, {Warren L} and Martens, {Timothy P.} and Eng, {George M.} and Milica Radisic and Gordana Vunjak-Novakovic",
year = "2009",
month = "8",
doi = "10.1016/j.semcdb.2008.12.008",
language = "English (US)",
volume = "20",
pages = "665--673",
journal = "Seminars in Cell and Developmental Biology",
issn = "1084-9521",
publisher = "Academic Press Inc.",
number = "6",

}

TY - JOUR

T1 - Biomimetic approach to tissue engineering

AU - Grayson, Warren L

AU - Martens, Timothy P.

AU - Eng, George M.

AU - Radisic, Milica

AU - Vunjak-Novakovic, Gordana

PY - 2009/8

Y1 - 2009/8

N2 - The overall goal of tissue engineering is to create functional tissue grafts that can regenerate or replace our defective or worn out tissues and organs. Examples of grafts that are now in pre-clinical studies or clinical use include engineered skin, cartilage, bone, blood vessels, skeletal muscle, bladder, trachea, and myocardium. Engineered tissues are also finding applications as platforms for pharmacological and physiological studies in vitro. To fully mobilize the cell's biological potential, a new generation of tissue engineering systems is now being developed to more closely recapitulate the native developmental milieu, and mimic the physiologic mechanisms of transport and signaling. We discuss the interactions between regenerative biology and engineering, in the context of (i) creation of functional tissue grafts for regenerative medicine (where biological input is critical), and (ii) studies of stem cells, development and disease (where engineered tissues can serve as advanced 3D models).

AB - The overall goal of tissue engineering is to create functional tissue grafts that can regenerate or replace our defective or worn out tissues and organs. Examples of grafts that are now in pre-clinical studies or clinical use include engineered skin, cartilage, bone, blood vessels, skeletal muscle, bladder, trachea, and myocardium. Engineered tissues are also finding applications as platforms for pharmacological and physiological studies in vitro. To fully mobilize the cell's biological potential, a new generation of tissue engineering systems is now being developed to more closely recapitulate the native developmental milieu, and mimic the physiologic mechanisms of transport and signaling. We discuss the interactions between regenerative biology and engineering, in the context of (i) creation of functional tissue grafts for regenerative medicine (where biological input is critical), and (ii) studies of stem cells, development and disease (where engineered tissues can serve as advanced 3D models).

KW - Bioreactor

KW - Electrical signals

KW - Perfusion

KW - Scaffold

KW - Stem cells

UR - http://www.scopus.com/inward/record.url?scp=67649454432&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649454432&partnerID=8YFLogxK

U2 - 10.1016/j.semcdb.2008.12.008

DO - 10.1016/j.semcdb.2008.12.008

M3 - Article

C2 - 19146967

AN - SCOPUS:67649454432

VL - 20

SP - 665

EP - 673

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

SN - 1084-9521

IS - 6

ER -