Biomimetic apoptotic erythrocyte membrane-coated microparticles for enhanced tolerance induction

Kelly R. Rhodes, Randall A. Meyer, Claire M. State, Jordan J. Green

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: To combat autoimmunity and promote immune tolerance, there is growing interest in therapies that exploit antigen presenting cell (APC)-mediated apoptotic clearance pathways. Tolerized APCs inhibit pathogenic effector T cells and promote formation of protective regulatory T cells.1 Delivery of self-antigen coupled to apoptotic cells has been shown to induce antigen-specific tolerance to treat autoimmune diseases such as multiple sclerosis without the need for broad immunosuppressants.2 However, cell-based therapies are expensive and complex to implement, and alternative “off-the-shelf" strategies are needed. Biocompatible micro-and nanocarriers coated with naturally-derived cell membranes possess key advantages of particle-based delivery platforms while retaining essential cell membrane features to activate apoptotic clearance pathways and promote tolerance. Here we investigate the ability of polymeric microparticles (MPs) with a novel apoptotic red blood cell (RBC)-derived surface coating to enhance APC-mediated tolerance induction. We demonstrate that this apoptotic coating speeds up clearance from systemic circulation, increases APC-mediated uptake, and promotes APC tolerization.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

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ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Rhodes, K. R., Meyer, R. A., State, C. M., & Green, J. J. (2019). Biomimetic apoptotic erythrocyte membrane-coated microparticles for enhanced tolerance induction. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.