TY - GEN
T1 - Biomechanically-constrained 4D estimation of myocardial motion
AU - Sundar, Hari
AU - Davatzikos, Christos
AU - Biros, George
PY - 2009
Y1 - 2009
N2 - We propose a method for the analysis of cardiac images with the goal of reconstructing the motion of the ventricular walls. The main feature of our method is that the inversion parameter field is the active contraction of the myocardial fibers. This is accomplished with a biophysically-constrained, four-dimensional (space plus time) formulation that aims to complement information that can be gathered from the images by a priori knowledge of cardiac mechanics. Our main hypothesis is that by incorporating biophysical information, we can generate more informative priors and thus, more accurate predictions of the ventricular wall motion. In this paper, we outline the formulation, discuss the computational methodology for solving the inverse motion estimation, and present preliminary validation using synthetic and tagged MR images. The overall method uses patient-specific imaging and fiber information to reconstruct the motion. In these preliminary tests, we verify the implementation and conduct a parametric study to test the sensitivity of the model to material properties perturbations, model errors, and incomplete and noisy observations.
AB - We propose a method for the analysis of cardiac images with the goal of reconstructing the motion of the ventricular walls. The main feature of our method is that the inversion parameter field is the active contraction of the myocardial fibers. This is accomplished with a biophysically-constrained, four-dimensional (space plus time) formulation that aims to complement information that can be gathered from the images by a priori knowledge of cardiac mechanics. Our main hypothesis is that by incorporating biophysical information, we can generate more informative priors and thus, more accurate predictions of the ventricular wall motion. In this paper, we outline the formulation, discuss the computational methodology for solving the inverse motion estimation, and present preliminary validation using synthetic and tagged MR images. The overall method uses patient-specific imaging and fiber information to reconstruct the motion. In these preliminary tests, we verify the implementation and conduct a parametric study to test the sensitivity of the model to material properties perturbations, model errors, and incomplete and noisy observations.
UR - http://www.scopus.com/inward/record.url?scp=84880196564&partnerID=8YFLogxK
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U2 - 10.1007/978-3-642-04271-3_32
DO - 10.1007/978-3-642-04271-3_32
M3 - Conference contribution
C2 - 20426120
AN - SCOPUS:84880196564
SN - 3642042708
SN - 9783642042706
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 257
EP - 265
BT - Medical Image Computing and Computer-Assisted Intervention - MICCAI2009 - 12th International Conference, Proceedings
T2 - 12th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2009
Y2 - 20 September 2009 through 24 September 2009
ER -