Biomaterials and Tissue Engineering for Soft Tissue Reconstruction

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The field of regenerative medicine utilizes biomaterial and cell-based approaches to regenerate damaged or diseased tissues. Current clinical strategies for soft tissue reconstruction highlight the need for regenerative medicine therapies. Patients who have significant soft tissue loss often require autologous flap reconstructions whereby tissue is removed from a donor site to repair the defect, resulting in donor site morbidity. Development of an off-the-shelf biomaterial for soft tissue regeneration could provide a readily available soft tissue replacement in cases of trauma or tumor resection. Researchers have investigated a wide range of biomaterial scaffolds for adipose tissue engineering, including synthetic polymers and naturally derived matrices. These scaffolds can be used alone or in conjunction with a cell source to facilitate tissue regeneration. These strategies for soft tissue repair can potentially stimulate regeneration of adipose tissue, obviating the need for donor site tissue to replace damaged soft connective tissues.

Original languageEnglish (US)
Title of host publicationNatural and Synthetic Biomedical Polymers
PublisherElsevier Inc.
Pages235-241
Number of pages7
ISBN (Print)9780123969835
DOIs
StatePublished - Jan 2014

Fingerprint

Biocompatible Materials
Tissue Engineering
Tissue engineering
Tissue
Regeneration
Regenerative Medicine
Tissue regeneration
Tissue Donors
Adipose Tissue
Repair
Connective Tissue
Scaffolds (biology)
Scaffolds
Polymers
Tumors
Research Personnel
Morbidity
Defects
Wounds and Injuries

Keywords

  • Adipose regeneration
  • Adipose tissue
  • Adipose tissue engineering
  • Extracellular matrix
  • Soft connective tissue
  • Soft tissue filler
  • Soft tissue reconstruction
  • Soft tissue repair

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Wu, I., & Elisseeff, J. H. (2014). Biomaterials and Tissue Engineering for Soft Tissue Reconstruction. In Natural and Synthetic Biomedical Polymers (pp. 235-241). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-396983-5.00015-6

Biomaterials and Tissue Engineering for Soft Tissue Reconstruction. / Wu, Iwen; Elisseeff, Jennifer Hartt.

Natural and Synthetic Biomedical Polymers. Elsevier Inc., 2014. p. 235-241.

Research output: Chapter in Book/Report/Conference proceedingChapter

Wu, I & Elisseeff, JH 2014, Biomaterials and Tissue Engineering for Soft Tissue Reconstruction. in Natural and Synthetic Biomedical Polymers. Elsevier Inc., pp. 235-241. https://doi.org/10.1016/B978-0-12-396983-5.00015-6
Wu, Iwen ; Elisseeff, Jennifer Hartt. / Biomaterials and Tissue Engineering for Soft Tissue Reconstruction. Natural and Synthetic Biomedical Polymers. Elsevier Inc., 2014. pp. 235-241
@inbook{76f54216cb664deaad84239985306e07,
title = "Biomaterials and Tissue Engineering for Soft Tissue Reconstruction",
abstract = "The field of regenerative medicine utilizes biomaterial and cell-based approaches to regenerate damaged or diseased tissues. Current clinical strategies for soft tissue reconstruction highlight the need for regenerative medicine therapies. Patients who have significant soft tissue loss often require autologous flap reconstructions whereby tissue is removed from a donor site to repair the defect, resulting in donor site morbidity. Development of an off-the-shelf biomaterial for soft tissue regeneration could provide a readily available soft tissue replacement in cases of trauma or tumor resection. Researchers have investigated a wide range of biomaterial scaffolds for adipose tissue engineering, including synthetic polymers and naturally derived matrices. These scaffolds can be used alone or in conjunction with a cell source to facilitate tissue regeneration. These strategies for soft tissue repair can potentially stimulate regeneration of adipose tissue, obviating the need for donor site tissue to replace damaged soft connective tissues.",
keywords = "Adipose regeneration, Adipose tissue, Adipose tissue engineering, Extracellular matrix, Soft connective tissue, Soft tissue filler, Soft tissue reconstruction, Soft tissue repair",
author = "Iwen Wu and Elisseeff, {Jennifer Hartt}",
year = "2014",
month = "1",
doi = "10.1016/B978-0-12-396983-5.00015-6",
language = "English (US)",
isbn = "9780123969835",
pages = "235--241",
booktitle = "Natural and Synthetic Biomedical Polymers",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Biomaterials and Tissue Engineering for Soft Tissue Reconstruction

AU - Wu, Iwen

AU - Elisseeff, Jennifer Hartt

PY - 2014/1

Y1 - 2014/1

N2 - The field of regenerative medicine utilizes biomaterial and cell-based approaches to regenerate damaged or diseased tissues. Current clinical strategies for soft tissue reconstruction highlight the need for regenerative medicine therapies. Patients who have significant soft tissue loss often require autologous flap reconstructions whereby tissue is removed from a donor site to repair the defect, resulting in donor site morbidity. Development of an off-the-shelf biomaterial for soft tissue regeneration could provide a readily available soft tissue replacement in cases of trauma or tumor resection. Researchers have investigated a wide range of biomaterial scaffolds for adipose tissue engineering, including synthetic polymers and naturally derived matrices. These scaffolds can be used alone or in conjunction with a cell source to facilitate tissue regeneration. These strategies for soft tissue repair can potentially stimulate regeneration of adipose tissue, obviating the need for donor site tissue to replace damaged soft connective tissues.

AB - The field of regenerative medicine utilizes biomaterial and cell-based approaches to regenerate damaged or diseased tissues. Current clinical strategies for soft tissue reconstruction highlight the need for regenerative medicine therapies. Patients who have significant soft tissue loss often require autologous flap reconstructions whereby tissue is removed from a donor site to repair the defect, resulting in donor site morbidity. Development of an off-the-shelf biomaterial for soft tissue regeneration could provide a readily available soft tissue replacement in cases of trauma or tumor resection. Researchers have investigated a wide range of biomaterial scaffolds for adipose tissue engineering, including synthetic polymers and naturally derived matrices. These scaffolds can be used alone or in conjunction with a cell source to facilitate tissue regeneration. These strategies for soft tissue repair can potentially stimulate regeneration of adipose tissue, obviating the need for donor site tissue to replace damaged soft connective tissues.

KW - Adipose regeneration

KW - Adipose tissue

KW - Adipose tissue engineering

KW - Extracellular matrix

KW - Soft connective tissue

KW - Soft tissue filler

KW - Soft tissue reconstruction

KW - Soft tissue repair

UR - http://www.scopus.com/inward/record.url?scp=84902945473&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902945473&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-396983-5.00015-6

DO - 10.1016/B978-0-12-396983-5.00015-6

M3 - Chapter

AN - SCOPUS:84902945473

SN - 9780123969835

SP - 235

EP - 241

BT - Natural and Synthetic Biomedical Polymers

PB - Elsevier Inc.

ER -