TY - JOUR
T1 - Biomarkers predicting malignant progression of laryngeal epithelial precursor lesions
T2 - A systematic review
AU - Rodrigo, Juan P.
AU - García-Pedrero, Juana María
AU - Suárez, Carlos
AU - Takes, Robert P.
AU - Thompson, Lester D.R.
AU - Slootweg, Pieter J.
AU - Woolgar, Julia A.
AU - Westra, William H.
AU - Brakenhoff, Ruud H.
AU - Rinaldo, Alessandra
AU - Devaney, Kenneth O.
AU - Williams, Michelle D.
AU - Gnepp, Douglas R.
AU - Ferlito, Alfio
PY - 2012/4/1
Y1 - 2012/4/1
N2 - Some laryngeal epithelial precursor lesions progress to invasive carcinoma and others do not. Routine light microscopic classification has limited value in predicting the evolution of these lesions. This article reviews the experience to date with the use of molecular markers for the prognostic evaluation of laryngeal epithelial precursor lesions. We conducted a thorough review of the published literature to identify those studies using biomarkers to predict malignant progression of laryngeal epithelial precursor lesions. Of the 336 studies identified in this systematic search, 15 met the inclusion criteria and form the basis of this review. Limited studies suggest that certain biomarkers are potentially reliable predictors of malignant progression including various regulators of cell adhesion and invasion (e.g. FAK, cortactin, osteopontin, and CD44v6) and proliferation-associated markers such as TGF-bRII and Kv3.4. The predictive value of these markers, however, has yet to be confirmed in large-scale prospective studies. Although the cell cycle-related proteins are the most frequently studied markers, none have been consistently reliable across multiple studies. The absence of standardization in methodologies, test interpretation, and other parameters may contribute to study inconsistencies. Various biomarkers have proved to have potential prognostic value and could be clinically relevant. The utility and prognostic power of these biomarkers should be confirmed in large, well-designed, standardized prospective studies.
AB - Some laryngeal epithelial precursor lesions progress to invasive carcinoma and others do not. Routine light microscopic classification has limited value in predicting the evolution of these lesions. This article reviews the experience to date with the use of molecular markers for the prognostic evaluation of laryngeal epithelial precursor lesions. We conducted a thorough review of the published literature to identify those studies using biomarkers to predict malignant progression of laryngeal epithelial precursor lesions. Of the 336 studies identified in this systematic search, 15 met the inclusion criteria and form the basis of this review. Limited studies suggest that certain biomarkers are potentially reliable predictors of malignant progression including various regulators of cell adhesion and invasion (e.g. FAK, cortactin, osteopontin, and CD44v6) and proliferation-associated markers such as TGF-bRII and Kv3.4. The predictive value of these markers, however, has yet to be confirmed in large-scale prospective studies. Although the cell cycle-related proteins are the most frequently studied markers, none have been consistently reliable across multiple studies. The absence of standardization in methodologies, test interpretation, and other parameters may contribute to study inconsistencies. Various biomarkers have proved to have potential prognostic value and could be clinically relevant. The utility and prognostic power of these biomarkers should be confirmed in large, well-designed, standardized prospective studies.
KW - Biomarkers
KW - Carcinoma in situ
KW - Dysplasia
KW - Epithelial precursor lesions
KW - Larynx
UR - http://www.scopus.com/inward/record.url?scp=84862871332&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862871332&partnerID=8YFLogxK
U2 - 10.1007/s00405-011-1831-4
DO - 10.1007/s00405-011-1831-4
M3 - Review article
C2 - 22081098
AN - SCOPUS:84862871332
VL - 269
SP - 1073
EP - 1083
JO - European Archives of Oto-Rhino-Laryngology
JF - European Archives of Oto-Rhino-Laryngology
SN - 0937-4477
IS - 4
ER -