Biomarkers of sarcopenia in clinical trials-recommendations from the International Working Group on Sarcopenia

Matteo Cesari, Roger A. Fielding, Marco Pahor, Bret Goodpaster, Marc Hellerstein, Gabor A. van Kan, Stefan D. Anker, Seward Rutkove, J. Willem Vrijbloed, Maria Isaac, Yves Rolland, Christine M'Rini, Mylène Aubertin-Leheudre, Jesse M. Cedarbaum, Mauro Zamboni, Cornell C. Sieber, Didier Laurent, William J. Evans, Ronenn Roubenoff, John E. MorleyBruno Vellas, Gabor Abellan van Kan, Sandrine Andrieu, Stefan D. Anker, Patricia Anthony, Christian Asbrand, Myl̀ne Aubertin-Leheudre, Sebastien Barbart-Artigas, Olivier Benichou, Cécile Bonhomme, Pascale Borensztein, Denis Breuillé, Sergio Castro Henriquez, Jesse M. Cedarbaum, Matteo Cesari, Patricia Chatelain, Wm Cameron Chumlea, Richard V. Clark, Capucine de Meynard, William J. Evans, Gary Fanjiang, Luigi Ferrucci, Roger A. Fielding, Philippe Garnier, Sophie Gillette-Guyonnet, Bret Goodpaster, Marie Françoise Gros, Luis Miguel F Gutierrez Robledo, Marc Hellerstein, Kelly Krohn, Maria Isaac, Didier Laurent, Menghua Luo, Hélène Matheix-Fortunet, Inge Mohede, John E. Morley, Christine M'Rini, Ramon Navarro, Bruno Oesch, Reinhard Ommerborn, Marco Pahor, Patrick Ritz, Yves Rolland, Daniel Rooks, Ronnen Roubenoff, Fariba Roughead, Seward Rutkove, Cornel C. Sieber, Michèle Storrs-Malibat, Stephanie Studenski, Yannis Tsouderos, Bruno Vellas, Sjors Verlaan, Stephan von Haehling, J. Willem Vrijbloed, Sander Wijers, Mauro Zamboni

Research output: Contribution to journalArticle

Abstract

Sarcopenia, the age-related skeletal muscle decline, is associated with relevant clinical and socioeconomic negative outcomes in older persons. The study of this phenomenon and the development of preventive/therapeutic strategies represent public health priorities. The present document reports the results of a recent meeting of the International Working Group on Sarcopenia (a task force consisting of geriatricians and scientists from academia and industry) held on June 7-8, 2011 in Toulouse (France). The meeting was specifically focused at gaining knowledge on the currently available biomarkers (functional, biological, or imaging-related) that could be utilized in clinical trials of sarcopenia and considered the most reliable and promising to evaluate age-related modifications of skeletal muscle. Specific recommendations about the assessment of aging skeletal muscle in older people and the optimal methodological design of studies on sarcopenia were also discussed and finalized. Although the study of skeletal muscle decline is still in a very preliminary phase, the potential great benefits derived from a better understanding and treatment of this condition should encourage research on sarcopenia. However, the reasonable uncertainties (derived from exploring a novel field and the exponential acceleration of scientific progress) require the adoption of a cautious and comprehensive approach to the subject.

Original languageEnglish (US)
Pages (from-to)181-190
Number of pages10
JournalJournal of Cachexia, Sarcopenia and Muscle
Volume3
Issue number3
DOIs
StatePublished - 2012
Externally publishedYes

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Sarcopenia
Biomarkers
Clinical Trials
Skeletal Muscle
Health Priorities
Advisory Committees
Uncertainty
France
Industry
Public Health
Therapeutics
Research

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physiology (medical)

Cite this

Cesari, M., Fielding, R. A., Pahor, M., Goodpaster, B., Hellerstein, M., van Kan, G. A., ... Zamboni, M. (2012). Biomarkers of sarcopenia in clinical trials-recommendations from the International Working Group on Sarcopenia. Journal of Cachexia, Sarcopenia and Muscle, 3(3), 181-190. https://doi.org/10.1007/s13539-012-0078-2

Biomarkers of sarcopenia in clinical trials-recommendations from the International Working Group on Sarcopenia. / Cesari, Matteo; Fielding, Roger A.; Pahor, Marco; Goodpaster, Bret; Hellerstein, Marc; van Kan, Gabor A.; Anker, Stefan D.; Rutkove, Seward; Vrijbloed, J. Willem; Isaac, Maria; Rolland, Yves; M'Rini, Christine; Aubertin-Leheudre, Mylène; Cedarbaum, Jesse M.; Zamboni, Mauro; Sieber, Cornell C.; Laurent, Didier; Evans, William J.; Roubenoff, Ronenn; Morley, John E.; Vellas, Bruno; van Kan, Gabor Abellan; Andrieu, Sandrine; Anker, Stefan D.; Anthony, Patricia; Asbrand, Christian; Aubertin-Leheudre, Myl̀ne; Barbart-Artigas, Sebastien; Benichou, Olivier; Bonhomme, Cécile; Borensztein, Pascale; Breuillé, Denis; Henriquez, Sergio Castro; Cedarbaum, Jesse M.; Cesari, Matteo; Chatelain, Patricia; Chumlea, Wm Cameron; Clark, Richard V.; de Meynard, Capucine; Evans, William J.; Fanjiang, Gary; Ferrucci, Luigi; Fielding, Roger A.; Garnier, Philippe; Gillette-Guyonnet, Sophie; Goodpaster, Bret; Gros, Marie Françoise; Gutierrez Robledo, Luis Miguel F; Hellerstein, Marc; Krohn, Kelly; Isaac, Maria; Laurent, Didier; Luo, Menghua; Matheix-Fortunet, Hélène; Mohede, Inge; Morley, John E.; M'Rini, Christine; Navarro, Ramon; Oesch, Bruno; Ommerborn, Reinhard; Pahor, Marco; Ritz, Patrick; Rolland, Yves; Rooks, Daniel; Roubenoff, Ronnen; Roughead, Fariba; Rutkove, Seward; Sieber, Cornel C.; Storrs-Malibat, Michèle; Studenski, Stephanie; Tsouderos, Yannis; Vellas, Bruno; Verlaan, Sjors; von Haehling, Stephan; Vrijbloed, J. Willem; Wijers, Sander; Zamboni, Mauro.

In: Journal of Cachexia, Sarcopenia and Muscle, Vol. 3, No. 3, 2012, p. 181-190.

Research output: Contribution to journalArticle

Cesari, M, Fielding, RA, Pahor, M, Goodpaster, B, Hellerstein, M, van Kan, GA, Anker, SD, Rutkove, S, Vrijbloed, JW, Isaac, M, Rolland, Y, M'Rini, C, Aubertin-Leheudre, M, Cedarbaum, JM, Zamboni, M, Sieber, CC, Laurent, D, Evans, WJ, Roubenoff, R, Morley, JE, Vellas, B, van Kan, GA, Andrieu, S, Anker, SD, Anthony, P, Asbrand, C, Aubertin-Leheudre, M, Barbart-Artigas, S, Benichou, O, Bonhomme, C, Borensztein, P, Breuillé, D, Henriquez, SC, Cedarbaum, JM, Cesari, M, Chatelain, P, Chumlea, WC, Clark, RV, de Meynard, C, Evans, WJ, Fanjiang, G, Ferrucci, L, Fielding, RA, Garnier, P, Gillette-Guyonnet, S, Goodpaster, B, Gros, MF, Gutierrez Robledo, LMF, Hellerstein, M, Krohn, K, Isaac, M, Laurent, D, Luo, M, Matheix-Fortunet, H, Mohede, I, Morley, JE, M'Rini, C, Navarro, R, Oesch, B, Ommerborn, R, Pahor, M, Ritz, P, Rolland, Y, Rooks, D, Roubenoff, R, Roughead, F, Rutkove, S, Sieber, CC, Storrs-Malibat, M, Studenski, S, Tsouderos, Y, Vellas, B, Verlaan, S, von Haehling, S, Vrijbloed, JW, Wijers, S & Zamboni, M 2012, 'Biomarkers of sarcopenia in clinical trials-recommendations from the International Working Group on Sarcopenia', Journal of Cachexia, Sarcopenia and Muscle, vol. 3, no. 3, pp. 181-190. https://doi.org/10.1007/s13539-012-0078-2
Cesari, Matteo ; Fielding, Roger A. ; Pahor, Marco ; Goodpaster, Bret ; Hellerstein, Marc ; van Kan, Gabor A. ; Anker, Stefan D. ; Rutkove, Seward ; Vrijbloed, J. Willem ; Isaac, Maria ; Rolland, Yves ; M'Rini, Christine ; Aubertin-Leheudre, Mylène ; Cedarbaum, Jesse M. ; Zamboni, Mauro ; Sieber, Cornell C. ; Laurent, Didier ; Evans, William J. ; Roubenoff, Ronenn ; Morley, John E. ; Vellas, Bruno ; van Kan, Gabor Abellan ; Andrieu, Sandrine ; Anker, Stefan D. ; Anthony, Patricia ; Asbrand, Christian ; Aubertin-Leheudre, Myl̀ne ; Barbart-Artigas, Sebastien ; Benichou, Olivier ; Bonhomme, Cécile ; Borensztein, Pascale ; Breuillé, Denis ; Henriquez, Sergio Castro ; Cedarbaum, Jesse M. ; Cesari, Matteo ; Chatelain, Patricia ; Chumlea, Wm Cameron ; Clark, Richard V. ; de Meynard, Capucine ; Evans, William J. ; Fanjiang, Gary ; Ferrucci, Luigi ; Fielding, Roger A. ; Garnier, Philippe ; Gillette-Guyonnet, Sophie ; Goodpaster, Bret ; Gros, Marie Françoise ; Gutierrez Robledo, Luis Miguel F ; Hellerstein, Marc ; Krohn, Kelly ; Isaac, Maria ; Laurent, Didier ; Luo, Menghua ; Matheix-Fortunet, Hélène ; Mohede, Inge ; Morley, John E. ; M'Rini, Christine ; Navarro, Ramon ; Oesch, Bruno ; Ommerborn, Reinhard ; Pahor, Marco ; Ritz, Patrick ; Rolland, Yves ; Rooks, Daniel ; Roubenoff, Ronnen ; Roughead, Fariba ; Rutkove, Seward ; Sieber, Cornel C. ; Storrs-Malibat, Michèle ; Studenski, Stephanie ; Tsouderos, Yannis ; Vellas, Bruno ; Verlaan, Sjors ; von Haehling, Stephan ; Vrijbloed, J. Willem ; Wijers, Sander ; Zamboni, Mauro. / Biomarkers of sarcopenia in clinical trials-recommendations from the International Working Group on Sarcopenia. In: Journal of Cachexia, Sarcopenia and Muscle. 2012 ; Vol. 3, No. 3. pp. 181-190.
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T1 - Biomarkers of sarcopenia in clinical trials-recommendations from the International Working Group on Sarcopenia

AU - Cesari, Matteo

AU - Fielding, Roger A.

AU - Pahor, Marco

AU - Goodpaster, Bret

AU - Hellerstein, Marc

AU - van Kan, Gabor A.

AU - Anker, Stefan D.

AU - Rutkove, Seward

AU - Vrijbloed, J. Willem

AU - Isaac, Maria

AU - Rolland, Yves

AU - M'Rini, Christine

AU - Aubertin-Leheudre, Mylène

AU - Cedarbaum, Jesse M.

AU - Zamboni, Mauro

AU - Sieber, Cornell C.

AU - Laurent, Didier

AU - Evans, William J.

AU - Roubenoff, Ronenn

AU - Morley, John E.

AU - Vellas, Bruno

AU - van Kan, Gabor Abellan

AU - Andrieu, Sandrine

AU - Anker, Stefan D.

AU - Anthony, Patricia

AU - Asbrand, Christian

AU - Aubertin-Leheudre, Myl̀ne

AU - Barbart-Artigas, Sebastien

AU - Benichou, Olivier

AU - Bonhomme, Cécile

AU - Borensztein, Pascale

AU - Breuillé, Denis

AU - Henriquez, Sergio Castro

AU - Cedarbaum, Jesse M.

AU - Cesari, Matteo

AU - Chatelain, Patricia

AU - Chumlea, Wm Cameron

AU - Clark, Richard V.

AU - de Meynard, Capucine

AU - Evans, William J.

AU - Fanjiang, Gary

AU - Ferrucci, Luigi

AU - Fielding, Roger A.

AU - Garnier, Philippe

AU - Gillette-Guyonnet, Sophie

AU - Goodpaster, Bret

AU - Gros, Marie Françoise

AU - Gutierrez Robledo, Luis Miguel F

AU - Hellerstein, Marc

AU - Krohn, Kelly

AU - Isaac, Maria

AU - Laurent, Didier

AU - Luo, Menghua

AU - Matheix-Fortunet, Hélène

AU - Mohede, Inge

AU - Morley, John E.

AU - M'Rini, Christine

AU - Navarro, Ramon

AU - Oesch, Bruno

AU - Ommerborn, Reinhard

AU - Pahor, Marco

AU - Ritz, Patrick

AU - Rolland, Yves

AU - Rooks, Daniel

AU - Roubenoff, Ronnen

AU - Roughead, Fariba

AU - Rutkove, Seward

AU - Sieber, Cornel C.

AU - Storrs-Malibat, Michèle

AU - Studenski, Stephanie

AU - Tsouderos, Yannis

AU - Vellas, Bruno

AU - Verlaan, Sjors

AU - von Haehling, Stephan

AU - Vrijbloed, J. Willem

AU - Wijers, Sander

AU - Zamboni, Mauro

PY - 2012

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AB - Sarcopenia, the age-related skeletal muscle decline, is associated with relevant clinical and socioeconomic negative outcomes in older persons. The study of this phenomenon and the development of preventive/therapeutic strategies represent public health priorities. The present document reports the results of a recent meeting of the International Working Group on Sarcopenia (a task force consisting of geriatricians and scientists from academia and industry) held on June 7-8, 2011 in Toulouse (France). The meeting was specifically focused at gaining knowledge on the currently available biomarkers (functional, biological, or imaging-related) that could be utilized in clinical trials of sarcopenia and considered the most reliable and promising to evaluate age-related modifications of skeletal muscle. Specific recommendations about the assessment of aging skeletal muscle in older people and the optimal methodological design of studies on sarcopenia were also discussed and finalized. Although the study of skeletal muscle decline is still in a very preliminary phase, the potential great benefits derived from a better understanding and treatment of this condition should encourage research on sarcopenia. However, the reasonable uncertainties (derived from exploring a novel field and the exponential acceleration of scientific progress) require the adoption of a cautious and comprehensive approach to the subject.

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