Biomarkers of frailty in older persons.

L. Ferrucci, C. Cavazzini, A. Corsi, B. Bartali, C. R. Russo, F. Lauretani, L. Ferrucci, C. Cavazzini, A. M. Corsi, B. Bartali, C. R. Russo, F. Lauretani, S. Bandinelli, S. Bandinelli, J. M. Guralnik

Research output: Contribution to journalArticle

Abstract

Trajectories of health and functioning with age show extreme variability among different individuals. Normal aging implies a progressive decline of physiological reserve and ability to compensate, but it is compatible with autonomy over the entire life span. In frail, older persons the decline in functional reserve is accelerated and compensatory mechanisms start failing, with high risk of homeostasis disruption and consequent negative health outcomes. Frailty is currently conceptualized as an age-related alteration in physiology and pathology that results into a typical constellation of signs and symptoms. Although current attempts to identify frail, older individuals for clinical purposes are based on measures of mobility and motor performance, candidate biological markers that may characterize the frailty syndrome start to emerge in the literature. These potential markers include, but are not limited to, soluble mediators of the inflammatory response, hormones, free radicals, antioxidants and macro- and micro-nutrients. This is a research area undergoing a rapid, dynamic development that may profit from new ways of defining disability outcomes in epidemiological studies of the elderly.

Original languageEnglish (US)
Pages (from-to)10-15
Number of pages6
JournalJournal of Endocrinological Investigation
Volume25
Issue number10 Suppl
StatePublished - 2002
Externally publishedYes

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Biomarkers
Food
Health
Signs and Symptoms
Free Radicals
Epidemiologic Studies
Homeostasis
Antioxidants
Hormones
Pathology
Research

ASJC Scopus subject areas

  • Endocrinology

Cite this

Ferrucci, L., Cavazzini, C., Corsi, A., Bartali, B., Russo, C. R., Lauretani, F., ... Guralnik, J. M. (2002). Biomarkers of frailty in older persons. Journal of Endocrinological Investigation, 25(10 Suppl), 10-15.

Biomarkers of frailty in older persons. / Ferrucci, L.; Cavazzini, C.; Corsi, A.; Bartali, B.; Russo, C. R.; Lauretani, F.; Ferrucci, L.; Cavazzini, C.; Corsi, A. M.; Bartali, B.; Russo, C. R.; Lauretani, F.; Bandinelli, S.; Bandinelli, S.; Guralnik, J. M.

In: Journal of Endocrinological Investigation, Vol. 25, No. 10 Suppl, 2002, p. 10-15.

Research output: Contribution to journalArticle

Ferrucci, L, Cavazzini, C, Corsi, A, Bartali, B, Russo, CR, Lauretani, F, Ferrucci, L, Cavazzini, C, Corsi, AM, Bartali, B, Russo, CR, Lauretani, F, Bandinelli, S, Bandinelli, S & Guralnik, JM 2002, 'Biomarkers of frailty in older persons.', Journal of Endocrinological Investigation, vol. 25, no. 10 Suppl, pp. 10-15.
Ferrucci L, Cavazzini C, Corsi A, Bartali B, Russo CR, Lauretani F et al. Biomarkers of frailty in older persons. Journal of Endocrinological Investigation. 2002;25(10 Suppl):10-15.
Ferrucci, L. ; Cavazzini, C. ; Corsi, A. ; Bartali, B. ; Russo, C. R. ; Lauretani, F. ; Ferrucci, L. ; Cavazzini, C. ; Corsi, A. M. ; Bartali, B. ; Russo, C. R. ; Lauretani, F. ; Bandinelli, S. ; Bandinelli, S. ; Guralnik, J. M. / Biomarkers of frailty in older persons. In: Journal of Endocrinological Investigation. 2002 ; Vol. 25, No. 10 Suppl. pp. 10-15.
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