Biomarkers in pediatrics: Children as biomarker orphans

William J. Savage, Allen D. Everett

Research output: Contribution to journalReview articlepeer-review


Biomarkers have enormous potential to improve patient care by establishing tests of diagnosis, prognosis, and treatment effects. Successfully translating a biomarker from discovery to clinical application demands high-quality discovery research and high-quality clinical studies for biomarker validation; however, there are additional challenges that face biomarker research in pediatrics. There are also additional characteristics of pediatric medicine that make biomarker research especially needed. This review focuses on the fundamentals of biomarkers, the additional considerations needed for applying biomarker research to children, and recommendations for advancing pediatric biomarker research.

Original languageEnglish (US)
Pages (from-to)915-921
Number of pages7
JournalProteomics - Clinical Applications
Issue number12
StatePublished - Dec 2010


  • Biomarker
  • Pediatrics

ASJC Scopus subject areas

  • Clinical Biochemistry


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