Biomarkers for knee osteoarthritis

New technologies, new paradigms

Lucy Spain, Bashar Rajoub, Daniela K. Schlüter, John Waterton, Mike Bowes, Lik Kwan Shark, Peter Diggle, John Goodacre

Research output: Contribution to journalArticle

Abstract

There is a paucity of biomarkers in knee osteoarthritis (OA) to inform clinical decision making, evaluate treatments, enable early detection and identify people who are most likely to progress to severe OA. The absence of biomarkers places considerable limitations on the design of research studies, and is a barrier toward applying the principles of stratified medicine to knee OA. Here we describe key principles and processes of biomarker development and focus on two promising areas that draw upon technologies that have only relatively recently been developed for quantitative applications in clinical research, namely 3D MRI and acoustic emission. While still at an early stage, results to date show promising potential to open up interesting new paradigms in this field.

Original languageEnglish (US)
Pages (from-to)287-297
Number of pages11
JournalInternational Journal of Clinical Rheumatology
Volume10
Issue number4
DOIs
StatePublished - Aug 1 2015
Externally publishedYes

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Knee Osteoarthritis
Biomarkers
Technology
Acoustics
Osteoarthritis
Research Design
Medicine
Research

Keywords

  • 3D MRI
  • acoustic emission
  • biomarker
  • knee osteoarthritis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Spain, L., Rajoub, B., Schlüter, D. K., Waterton, J., Bowes, M., Shark, L. K., ... Goodacre, J. (2015). Biomarkers for knee osteoarthritis: New technologies, new paradigms. International Journal of Clinical Rheumatology, 10(4), 287-297. https://doi.org/10.2217/ijr.15.32

Biomarkers for knee osteoarthritis : New technologies, new paradigms. / Spain, Lucy; Rajoub, Bashar; Schlüter, Daniela K.; Waterton, John; Bowes, Mike; Shark, Lik Kwan; Diggle, Peter; Goodacre, John.

In: International Journal of Clinical Rheumatology, Vol. 10, No. 4, 01.08.2015, p. 287-297.

Research output: Contribution to journalArticle

Spain, L, Rajoub, B, Schlüter, DK, Waterton, J, Bowes, M, Shark, LK, Diggle, P & Goodacre, J 2015, 'Biomarkers for knee osteoarthritis: New technologies, new paradigms', International Journal of Clinical Rheumatology, vol. 10, no. 4, pp. 287-297. https://doi.org/10.2217/ijr.15.32
Spain L, Rajoub B, Schlüter DK, Waterton J, Bowes M, Shark LK et al. Biomarkers for knee osteoarthritis: New technologies, new paradigms. International Journal of Clinical Rheumatology. 2015 Aug 1;10(4):287-297. https://doi.org/10.2217/ijr.15.32
Spain, Lucy ; Rajoub, Bashar ; Schlüter, Daniela K. ; Waterton, John ; Bowes, Mike ; Shark, Lik Kwan ; Diggle, Peter ; Goodacre, John. / Biomarkers for knee osteoarthritis : New technologies, new paradigms. In: International Journal of Clinical Rheumatology. 2015 ; Vol. 10, No. 4. pp. 287-297.
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