Biomarkers for early detection of Alzheimer pathology

C. M. Clark, C. Davatzikos, A. Borthakur, A. Newberg, S. Leight, V. M.Y. Lee, J. Q. Trojanowski

Research output: Contribution to journalReview articlepeer-review

Abstract

The increasing prevalence of Alzheimer's disease and the devastating consequences of late-life dementia motivates the drive to develop diagnostic biomarkers to reliably identify the pathology associated with this disorder. Strategies to accomplish this include the detection of altered levels of tau and amyloid in cerebrospinal fluid, the use of structural MRI to identify disease-specific patterns of regional atrophy and MRI T1ρ to detect disease-related macromolecular protein aggregation, and the direct imaging of amyloid deposits using positron emission tomography and single photon emission computerized tomography. Success will facilitate the ability to reliably diagnose Alzheimer's disease while the symptoms of brain failure are mild and may provide objective measures of disease-modifying treatment efficacy.

Original languageEnglish (US)
Pages (from-to)11-18
Number of pages8
JournalNeuroSignals
Volume16
Issue number1
DOIs
StatePublished - Dec 2007

Keywords

  • Alzheimer's disease
  • Biomarkers
  • Diagnosis
  • Neurodegenerative disease

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

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