Biomarkers for early detection of Alzheimer pathology

C. M. Clark, C. Davatzikos, A. Borthakur, A. Newberg, S. Leight, V. M Y Lee, J. Q. Trojanowski

Research output: Contribution to journalArticle

Abstract

The increasing prevalence of Alzheimer's disease and the devastating consequences of late-life dementia motivates the drive to develop diagnostic biomarkers to reliably identify the pathology associated with this disorder. Strategies to accomplish this include the detection of altered levels of tau and amyloid in cerebrospinal fluid, the use of structural MRI to identify disease-specific patterns of regional atrophy and MRI T1ρ to detect disease-related macromolecular protein aggregation, and the direct imaging of amyloid deposits using positron emission tomography and single photon emission computerized tomography. Success will facilitate the ability to reliably diagnose Alzheimer's disease while the symptoms of brain failure are mild and may provide objective measures of disease-modifying treatment efficacy.

Original languageEnglish (US)
Pages (from-to)11-18
Number of pages8
JournalNeuroSignals
Volume16
Issue number1
DOIs
StatePublished - Dec 2007
Externally publishedYes

Fingerprint

Biomarkers
Pathology
Alzheimer Disease
Aptitude
Amyloid Plaques
Single-Photon Emission-Computed Tomography
Amyloid
Positron-Emission Tomography
Atrophy
Cerebrospinal Fluid
Dementia
Brain
Proteins
Drive

Keywords

  • Alzheimer's disease
  • Biomarkers
  • Diagnosis
  • Neurodegenerative disease

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Clark, C. M., Davatzikos, C., Borthakur, A., Newberg, A., Leight, S., Lee, V. M. Y., & Trojanowski, J. Q. (2007). Biomarkers for early detection of Alzheimer pathology. NeuroSignals, 16(1), 11-18. https://doi.org/10.1159/000109754

Biomarkers for early detection of Alzheimer pathology. / Clark, C. M.; Davatzikos, C.; Borthakur, A.; Newberg, A.; Leight, S.; Lee, V. M Y; Trojanowski, J. Q.

In: NeuroSignals, Vol. 16, No. 1, 12.2007, p. 11-18.

Research output: Contribution to journalArticle

Clark, CM, Davatzikos, C, Borthakur, A, Newberg, A, Leight, S, Lee, VMY & Trojanowski, JQ 2007, 'Biomarkers for early detection of Alzheimer pathology', NeuroSignals, vol. 16, no. 1, pp. 11-18. https://doi.org/10.1159/000109754
Clark CM, Davatzikos C, Borthakur A, Newberg A, Leight S, Lee VMY et al. Biomarkers for early detection of Alzheimer pathology. NeuroSignals. 2007 Dec;16(1):11-18. https://doi.org/10.1159/000109754
Clark, C. M. ; Davatzikos, C. ; Borthakur, A. ; Newberg, A. ; Leight, S. ; Lee, V. M Y ; Trojanowski, J. Q. / Biomarkers for early detection of Alzheimer pathology. In: NeuroSignals. 2007 ; Vol. 16, No. 1. pp. 11-18.
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