TY - JOUR
T1 - Biomarkers for diagnosis and prognosis of AKI in children
T2 - One size does not fit all
AU - Greenberg, Jason H.
AU - Parikh, Chirag R.
N1 - Funding Information:
This study was supported by the National Institutes of Health (NIH) (R01HL085757 to C.R.P.) to fund the Translational Research Investigating Biomarker Endpoints in AKI Consortium to study novel biomarkers of AKI in cardiac surgery. J.H.G. is supported by the National Institute of Diabetes and Digestive and Kidney Diseases of the NIH under award number K08DK110536. C.R.P. is supported by the NIH (K24DK090203) and P30 DK079310-07 O’Brien Center Grant. C.R.P. is also a member of the NIH-sponsored Access, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury Consortium (U01DK082185).
Publisher Copyright:
© 2017 by the American Society of Nephrology.
PY - 2017/9/7
Y1 - 2017/9/7
N2 - Pediatric AKI has become a significant health concern due to its rising incidence and association with adverse outcomes. Because of the limitations of serum creatinine, ongoing research has evaluated multiple novel biomarkers for the early detection of AKI. Identifying biomarkers that precede changes in serum creatinine is vital, because these biomarkers provide opportunities to improve outcomes through early diagnosis and timely disease management. In this review, we discuss salient findings on 16 candidate biomarkers and their association with AKI. We explore the differences in biomarker distribution by age and discuss why adult biomarker research findings cannot be directly extrapolated to children. With future research, more consideration needs to be given to how the maturing kidney affects biomarker levels and how we interpret biomarker performance in children. A comprehensive approach using age-specific biomarker reference ranges is required to develop pediatric biomarkers and improve outcomes for children with kidney disease.
AB - Pediatric AKI has become a significant health concern due to its rising incidence and association with adverse outcomes. Because of the limitations of serum creatinine, ongoing research has evaluated multiple novel biomarkers for the early detection of AKI. Identifying biomarkers that precede changes in serum creatinine is vital, because these biomarkers provide opportunities to improve outcomes through early diagnosis and timely disease management. In this review, we discuss salient findings on 16 candidate biomarkers and their association with AKI. We explore the differences in biomarker distribution by age and discuss why adult biomarker research findings cannot be directly extrapolated to children. With future research, more consideration needs to be given to how the maturing kidney affects biomarker levels and how we interpret biomarker performance in children. A comprehensive approach using age-specific biomarker reference ranges is required to develop pediatric biomarkers and improve outcomes for children with kidney disease.
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U2 - 10.2215/CJN.12851216
DO - 10.2215/CJN.12851216
M3 - Article
C2 - 28667085
AN - SCOPUS:85029600916
VL - 12
SP - 1551
EP - 1557
JO - Clinical journal of the American Society of Nephrology : CJASN
JF - Clinical journal of the American Society of Nephrology : CJASN
SN - 1555-9041
IS - 9
ER -