Abstract
Pediatric AKI has become a significant health concern due to its rising incidence and association with adverse outcomes. Because of the limitations of serum creatinine, ongoing research has evaluated multiple novel biomarkers for the early detection of AKI. Identifying biomarkers that precede changes in serum creatinine is vital, because these biomarkers provide opportunities to improve outcomes through early diagnosis and timely disease management. In this review, we discuss salient findings on 16 candidate biomarkers and their association with AKI. We explore the differences in biomarker distribution by age and discuss why adult biomarker research findings cannot be directly extrapolated to children. With future research, more consideration needs to be given to how the maturing kidney affects biomarker levels and how we interpret biomarker performance in children. A comprehensive approach using age-specific biomarker reference ranges is required to develop pediatric biomarkers and improve outcomes for children with kidney disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1551-1557 |
| Number of pages | 7 |
| Journal | Clinical Journal of the American Society of Nephrology |
| Volume | 12 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 7 2017 |
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ASJC Scopus subject areas
- Epidemiology
- Critical Care and Intensive Care Medicine
- Nephrology
- Transplantation
Cite this
Biomarkers for diagnosis and prognosis of AKI in children : One size does not fit all. / Greenberg, Jason H.; Parikh, Chirag.
In: Clinical Journal of the American Society of Nephrology, Vol. 12, No. 9, 07.09.2017, p. 1551-1557.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Biomarkers for diagnosis and prognosis of AKI in children
T2 - One size does not fit all
AU - Greenberg, Jason H.
AU - Parikh, Chirag
PY - 2017/9/7
Y1 - 2017/9/7
N2 - Pediatric AKI has become a significant health concern due to its rising incidence and association with adverse outcomes. Because of the limitations of serum creatinine, ongoing research has evaluated multiple novel biomarkers for the early detection of AKI. Identifying biomarkers that precede changes in serum creatinine is vital, because these biomarkers provide opportunities to improve outcomes through early diagnosis and timely disease management. In this review, we discuss salient findings on 16 candidate biomarkers and their association with AKI. We explore the differences in biomarker distribution by age and discuss why adult biomarker research findings cannot be directly extrapolated to children. With future research, more consideration needs to be given to how the maturing kidney affects biomarker levels and how we interpret biomarker performance in children. A comprehensive approach using age-specific biomarker reference ranges is required to develop pediatric biomarkers and improve outcomes for children with kidney disease.
AB - Pediatric AKI has become a significant health concern due to its rising incidence and association with adverse outcomes. Because of the limitations of serum creatinine, ongoing research has evaluated multiple novel biomarkers for the early detection of AKI. Identifying biomarkers that precede changes in serum creatinine is vital, because these biomarkers provide opportunities to improve outcomes through early diagnosis and timely disease management. In this review, we discuss salient findings on 16 candidate biomarkers and their association with AKI. We explore the differences in biomarker distribution by age and discuss why adult biomarker research findings cannot be directly extrapolated to children. With future research, more consideration needs to be given to how the maturing kidney affects biomarker levels and how we interpret biomarker performance in children. A comprehensive approach using age-specific biomarker reference ranges is required to develop pediatric biomarkers and improve outcomes for children with kidney disease.
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UR - http://www.scopus.com/inward/citedby.url?scp=85029600916&partnerID=8YFLogxK
U2 - 10.2215/CJN.12851216
DO - 10.2215/CJN.12851216
M3 - Article
C2 - 28667085
AN - SCOPUS:85029600916
VL - 12
SP - 1551
EP - 1557
JO - Clinical journal of the American Society of Nephrology : CJASN
JF - Clinical journal of the American Society of Nephrology : CJASN
SN - 1555-9041
IS - 9
ER -