Biomarker identification for early tumor detection aided by bioinformatics gene expression analysis

Wanling Yang, Peng Huang, Minghui Zhao, Yu Lung Lau

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Early detection of cancer is key to prompt treatment and patient's long term survival. Designing noninvasive and simple methodologies that can be used in large scale screening for early tumor detection is an important research area that could have profound impact on cancer prevention and treatment. Taking advantage of available gene expression databases, we have performed extensive analysis on differentially expressed (DE) genes and alternatively spliced (AS) forms of genes in cancer tissues. In this study we detected genes that are potentially up-regulated in tumor tissues comparing to normal tissues. We also aligned the 8 million human EST sequences in dbEST with human genomic sequences, and found several hundreds AS variants that have a potential to be specific to or overexpressed in tumor tissues comparing to normal tissues. Our results showed the possibility of using gene expression databases to detect potential "cancer genes", and to use those DS genes and AS variants of genes as markers for early cancer detection.

Original languageEnglish (US)
Title of host publicationBioMedical Engineering and Informatics
Subtitle of host publicationNew Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008
Pages469-473
Number of pages5
DOIs
StatePublished - Sep 17 2008
Externally publishedYes
EventBioMedical Engineering and Informatics: New Development and the Future - 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008 - Sanya, Hainan, China
Duration: May 27 2008May 30 2008

Publication series

NameBioMedical Engineering and Informatics: New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008
Volume1

Other

OtherBioMedical Engineering and Informatics: New Development and the Future - 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008
CountryChina
CitySanya, Hainan
Period5/27/085/30/08

ASJC Scopus subject areas

  • Information Systems
  • Signal Processing
  • Biomedical Engineering

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  • Cite this

    Yang, W., Huang, P., Zhao, M., & Lau, Y. L. (2008). Biomarker identification for early tumor detection aided by bioinformatics gene expression analysis. In BioMedical Engineering and Informatics: New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008 (pp. 469-473). [4548713] (BioMedical Engineering and Informatics: New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008; Vol. 1). https://doi.org/10.1109/BMEI.2008.230