Biomarker identification for diagnosis of schizophrenia with integrated analysis of fMRI and SNPs

Hongbao Cao, Dongdong Lin, Junbo Duan, Yu Ping Wang, Vince Calhoun

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

It is important to identify significant biomarkers such as SNPs for medical diagnosis and treatment. However, the size of a biological sample is usually far less than the number of measurements, which makes the problem more challenging. To overcome this difficulty, we propose a sparse representation based variable selection (SRVS) approach. A simulated data set was first tested to demonstrate the advantages and properties of the proposed method. Then, we applied the algorithm to a joint analysis of 759075 SNPs and 153594 functional magnetic resonance imaging (fMRJ) voxels in 208 subjects (92 cases/116 controls) to identify significant biomarkers for schizophrenia (SZ). When compared with previous studies, our proposed method located 20 genes out of the top 45 SZ genes that are publicly reported We also detected some interesting functional brain regions from the fMRI study. In addition, a leave one out (LOO) cross-validation was performed and the results were compared with that of a previously reported method, which showed that our method gave significantly higher classification accuracy. In addition, the identification accuracy with integrative analysis is much better than that of using single type of data, suggesting that integrative analysis may lead to better diagnostic accuracy by combining complementary SNP and fMRI data.

Original languageEnglish (US)
Title of host publicationProceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2012
Pages223-228
Number of pages6
DOIs
StatePublished - Dec 1 2012
Externally publishedYes
Event2012 IEEE International Conference on Bioinformatics and Biomedicine, BIBM2012 - Philadelphia, PA, United States
Duration: Oct 4 2012Oct 7 2012

Publication series

NameProceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2012

Other

Other2012 IEEE International Conference on Bioinformatics and Biomedicine, BIBM2012
CountryUnited States
CityPhiladelphia, PA
Period10/4/1210/7/12

Keywords

  • Integrated analysis
  • SNP
  • Sparse representations
  • Variable selection
  • fMRI

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics

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