TY - JOUR
T1 - Biomarker analysis by fluorokine multianalyte profiling distinguishes patients requiring intervention from patients with long-term quiescent coronary artery disease
T2 - A potential approach to identify atherosclerotic disease progression
AU - Gurbel, Paul A.
AU - Kreutz, Rolf P.
AU - Bliden, Kevin P.
AU - DiChiara, Joseph
AU - Tantry, Udaya S.
N1 - Funding Information:
The study was supported by Bayer HealthCare LLC, Morristown, NJ, and Sinai Hospital of Baltimore.
PY - 2008/1
Y1 - 2008/1
N2 - Background: The study rationale was to compare the biomarker profile of metalloproteinases (MMPs) and inflammation markers (IMs) in patients requiring revascularization with that of patients with long-term, clinically quiescent coronary artery disease (CAD). Methods: Seventy-eight patients with symptomatic CAD (S-CAD) (7 patients with myocardial infarction and 71 patients with stable angina) and 67 patients with asymptomatic CAD (A-CAD) were enrolled. Plasma samples were analyzed for MMPs, MMP inhibitors (MMPIs), IMs, coagulation factors, and apolipoproteins by use of the fluorokine multianalyte profiling assay. Results: Patients with S-CAD had markedly elevated levels of specific MMPs (MMP-2, MMP-9), MMPIs (α2-macroglobulin, tissue inhibitor of MMP 1), IMs (C-reactive protein; interleukin [IL] 8; IL-10, regulated upon activation, normal T-cell expressed and secreted [RANTES], endothelin, plasminogen activator inhibitor 1, and apolipoprotein C-III compared with patients with A-CAD (P < .005 for all measurements), whereas patients with A-CAD had significantly greater levels of MMP-3 and IL-1α compared with patients with S-CAD (P ≤ .02 for both measurements). Conclusions: A specific profile of MMPs, IMs, and other biomarkers distinguishes the patient with progressive coronary atherosclerosis culminating in either elective or emergent percutaneous coronary intervention from the patient with quiescent disease. The early implementation of a biomarker analysis may identify the patient at risk for plaque progression and refine the definition of "stable" angina.
AB - Background: The study rationale was to compare the biomarker profile of metalloproteinases (MMPs) and inflammation markers (IMs) in patients requiring revascularization with that of patients with long-term, clinically quiescent coronary artery disease (CAD). Methods: Seventy-eight patients with symptomatic CAD (S-CAD) (7 patients with myocardial infarction and 71 patients with stable angina) and 67 patients with asymptomatic CAD (A-CAD) were enrolled. Plasma samples were analyzed for MMPs, MMP inhibitors (MMPIs), IMs, coagulation factors, and apolipoproteins by use of the fluorokine multianalyte profiling assay. Results: Patients with S-CAD had markedly elevated levels of specific MMPs (MMP-2, MMP-9), MMPIs (α2-macroglobulin, tissue inhibitor of MMP 1), IMs (C-reactive protein; interleukin [IL] 8; IL-10, regulated upon activation, normal T-cell expressed and secreted [RANTES], endothelin, plasminogen activator inhibitor 1, and apolipoprotein C-III compared with patients with A-CAD (P < .005 for all measurements), whereas patients with A-CAD had significantly greater levels of MMP-3 and IL-1α compared with patients with S-CAD (P ≤ .02 for both measurements). Conclusions: A specific profile of MMPs, IMs, and other biomarkers distinguishes the patient with progressive coronary atherosclerosis culminating in either elective or emergent percutaneous coronary intervention from the patient with quiescent disease. The early implementation of a biomarker analysis may identify the patient at risk for plaque progression and refine the definition of "stable" angina.
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U2 - 10.1016/j.ahj.2007.08.021
DO - 10.1016/j.ahj.2007.08.021
M3 - Article
C2 - 18082490
AN - SCOPUS:36849065911
SN - 0002-8703
VL - 155
SP - 56
EP - 61
JO - American heart journal
JF - American heart journal
IS - 1
ER -