Biomanufacturing in low Earth orbit for regenerative medicine

Arun Sharma; Rachel A. Clemens; Orquidea Garcia; D. Lansing Taylor; Nicole L. Wagner; Kelly A. Shepard; Anjali Gupta; Siobhan Malany; Alan J. Grodzinsky; Mary Kearns-Jonker; Devin B. Mair; Deok Ho Kim; Michael S. Roberts; Jeanne F. Loring; Jianying Hu; Lara E. Warren; Sven Eenmaa; Joe Bozada; Eric Paljug; Mark Roth; Donald P. Taylor; Gary Rodrigue; Patrick Cantini; Amelia W. Smith; Marc A. Giulianotti; William R. Wagner

doi:10.1016/j.stemcr.2021.12.001

Biomanufacturing in low Earth orbit for regenerative medicine

Arun Sharma, Rachel A. Clemens, Orquidea Garcia, D. Lansing Taylor, Nicole L. Wagner, Kelly A. Shepard, Anjali Gupta, Siobhan Malany, Alan J. Grodzinsky, Mary Kearns-Jonker, Devin B. Mair, Deok Ho Kim, Michael S. Roberts, Jeanne F. Loring, Jianying Hu, Lara E. Warren, Sven Eenmaa, Joe Bozada, Eric Paljug, Mark RothDonald P. Taylor, Gary Rodrigue, Patrick Cantini, Amelia W. Smith, Marc A. Giulianotti, William R. Wagner

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Research in low Earth orbit (LEO) has become more accessible. The 2020 Biomanufacturing in Space Symposium reviewed space-based regenerative medicine research and discussed leveraging LEO to advance biomanufacturing for regenerative medicine applications. The symposium identified areas where financial investments could stimulate advancements overcoming technical barriers. Opportunities in disease modeling, stem-cell-derived products, and biofabrication were highlighted. The symposium will initiate a roadmap to a sustainable market for regenerative medicine biomanufacturing in space. This perspective summarizes the 2020 Biomanufacturing in Space Symposium, highlights key biomanufacturing opportunities in LEO, and lays the framework for a roadmap to regenerative medicine biomanufacturing in space.

Original language	English (US)
Pages (from-to)	1-13
Number of pages	13
Journal	Stem Cell Reports
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/j.stemcr.2021.12.001
State	Published - Jan 11 2022

Keywords

biofabrication
microgravity
microphysiological systems
organoids
stem cells

ASJC Scopus subject areas

Genetics
Biochemistry
Cell Biology
Developmental Biology

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10.1016/j.stemcr.2021.12.001

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Sharma, A., Clemens, R. A., Garcia, O., Taylor, D. L., Wagner, N. L., Shepard, K. A., Gupta, A., Malany, S., Grodzinsky, A. J., Kearns-Jonker, M., Mair, D. B., Kim, D. H., Roberts, M. S., Loring, J. F., Hu, J., Warren, L. E., Eenmaa, S., Bozada, J., Paljug, E., ... Wagner, W. R. (2022). Biomanufacturing in low Earth orbit for regenerative medicine. Stem Cell Reports, 17(1), 1-13. https://doi.org/10.1016/j.stemcr.2021.12.001

Sharma, A, Clemens, RA, Garcia, O, Taylor, DL, Wagner, NL, Shepard, KA, Gupta, A, Malany, S, Grodzinsky, AJ, Kearns-Jonker, M, Mair, DB, Kim, DH, Roberts, MS, Loring, JF, Hu, J, Warren, LE, Eenmaa, S, Bozada, J, Paljug, E, Roth, M, Taylor, DP, Rodrigue, G, Cantini, P, Smith, AW, Giulianotti, MA & Wagner, WR 2022, 'Biomanufacturing in low Earth orbit for regenerative medicine', Stem Cell Reports, vol. 17, no. 1, pp. 1-13. https://doi.org/10.1016/j.stemcr.2021.12.001

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title = "Biomanufacturing in low Earth orbit for regenerative medicine",

abstract = "Research in low Earth orbit (LEO) has become more accessible. The 2020 Biomanufacturing in Space Symposium reviewed space-based regenerative medicine research and discussed leveraging LEO to advance biomanufacturing for regenerative medicine applications. The symposium identified areas where financial investments could stimulate advancements overcoming technical barriers. Opportunities in disease modeling, stem-cell-derived products, and biofabrication were highlighted. The symposium will initiate a roadmap to a sustainable market for regenerative medicine biomanufacturing in space. This perspective summarizes the 2020 Biomanufacturing in Space Symposium, highlights key biomanufacturing opportunities in LEO, and lays the framework for a roadmap to regenerative medicine biomanufacturing in space.",

keywords = "biofabrication, microgravity, microphysiological systems, organoids, stem cells",

author = "Arun Sharma and Clemens, {Rachel A.} and Orquidea Garcia and Taylor, {D. Lansing} and Wagner, {Nicole L.} and Shepard, {Kelly A.} and Anjali Gupta and Siobhan Malany and Grodzinsky, {Alan J.} and Mary Kearns-Jonker and Mair, {Devin B.} and Kim, {Deok Ho} and Roberts, {Michael S.} and Loring, {Jeanne F.} and Jianying Hu and Warren, {Lara E.} and Sven Eenmaa and Joe Bozada and Eric Paljug and Mark Roth and Taylor, {Donald P.} and Gary Rodrigue and Patrick Cantini and Smith, {Amelia W.} and Giulianotti, {Marc A.} and Wagner, {William R.}",

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AU - Clemens, Rachel A.

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AU - Taylor, D. Lansing

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AU - Shepard, Kelly A.

AU - Gupta, Anjali

AU - Malany, Siobhan

AU - Grodzinsky, Alan J.

AU - Kearns-Jonker, Mary

AU - Mair, Devin B.

AU - Kim, Deok Ho

AU - Roberts, Michael S.

AU - Loring, Jeanne F.

AU - Hu, Jianying

AU - Warren, Lara E.

AU - Eenmaa, Sven

AU - Bozada, Joe

AU - Paljug, Eric

AU - Roth, Mark

AU - Taylor, Donald P.

AU - Rodrigue, Gary

AU - Cantini, Patrick

AU - Smith, Amelia W.

AU - Giulianotti, Marc A.

AU - Wagner, William R.

PY - 2022/1/11

Y1 - 2022/1/11

N2 - Research in low Earth orbit (LEO) has become more accessible. The 2020 Biomanufacturing in Space Symposium reviewed space-based regenerative medicine research and discussed leveraging LEO to advance biomanufacturing for regenerative medicine applications. The symposium identified areas where financial investments could stimulate advancements overcoming technical barriers. Opportunities in disease modeling, stem-cell-derived products, and biofabrication were highlighted. The symposium will initiate a roadmap to a sustainable market for regenerative medicine biomanufacturing in space. This perspective summarizes the 2020 Biomanufacturing in Space Symposium, highlights key biomanufacturing opportunities in LEO, and lays the framework for a roadmap to regenerative medicine biomanufacturing in space.

AB - Research in low Earth orbit (LEO) has become more accessible. The 2020 Biomanufacturing in Space Symposium reviewed space-based regenerative medicine research and discussed leveraging LEO to advance biomanufacturing for regenerative medicine applications. The symposium identified areas where financial investments could stimulate advancements overcoming technical barriers. Opportunities in disease modeling, stem-cell-derived products, and biofabrication were highlighted. The symposium will initiate a roadmap to a sustainable market for regenerative medicine biomanufacturing in space. This perspective summarizes the 2020 Biomanufacturing in Space Symposium, highlights key biomanufacturing opportunities in LEO, and lays the framework for a roadmap to regenerative medicine biomanufacturing in space.

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KW - microgravity

KW - microphysiological systems

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KW - stem cells

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Biomanufacturing in low Earth orbit for regenerative medicine

Abstract

Keywords

ASJC Scopus subject areas

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