Biology of p62/sequestosome-1 in age-related macular degeneration (AMD)

Lei Wang, Katayoon B. Ebrahimi, Michelle Chyn, Marisol Cano, James T. Handa

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

p62/sequestosome-1 is a multidimensional protein that interacts with many signaling factors, and regulates a variety of cellular functions including inflammation, apoptosis, and autophagy. Our previous work has revealed in the retinal pigment epithelium (RPE) that p62 promotes autophagy and simultaneously enhances an Nrf2-mediated antioxidant response to protect against acute oxidative stress. Several recent studies demonstrated that p62 contributes to NFkB mediated inflammation and inflammasome activation under certain circumstances, raising the question of whether p62 protects against or contributes to tissue injury. Herein, we will review the general characteristics of p62, focusing on its pro- and anti-cell survival roles within different physiological/pathological contexts, and discuss the potential of p62 as a therapeutic target for AMD.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages17-22
Number of pages6
DOIs
StatePublished - Oct 1 2016

Publication series

NameAdvances in Experimental Medicine and Biology
Volume854
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

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Keywords

  • AMD
  • Autophagy
  • NFkB
  • Neurodegeneration
  • Nrf2
  • P62
  • PB1
  • RPE
  • Sqstm1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Wang, L., Ebrahimi, K. B., Chyn, M., Cano, M., & Handa, J. T. (2016). Biology of p62/sequestosome-1 in age-related macular degeneration (AMD). In Advances in Experimental Medicine and Biology (pp. 17-22). (Advances in Experimental Medicine and Biology; Vol. 854). Springer New York LLC. https://doi.org/10.1007/978-3-319-17121-0_3