Biology of Human Papillomavirus Infection and Immune Therapy for HPV-Related Head and Neck Cancers

Simon R. Best, Kevin J. Niparko, Sara I. Pai

Research output: Contribution to journalReview article

Abstract

This article outlines the biology of human papillomavirus (HPV) infection of human mucosa and the cellular pathways that are altered through viral infection. The article provides a conceptual framework with which to understand the 2 major immunologic strategies to address HPV-related diseases: (1) prevention of primary HPV infection through the use of prophylactic vaccines and (2) treatment of established infection and diseases through therapeutic vaccines. Nonimmunologic therapy that targets cellular dysregulation induced by HPV infection is also discussed. The challenges in actualizing these conceptually attractive therapies on both a societal and biological level are examined.

Original languageEnglish (US)
Pages (from-to)807-822
Number of pages16
JournalOtolaryngologic Clinics of North America
Volume45
Issue number4
DOIs
StatePublished - Aug 1 2012

Keywords

  • HPV-head and neck cancer
  • Immunotherapy
  • Oropharyngeal cancer
  • Vaccines

ASJC Scopus subject areas

  • Otorhinolaryngology

Fingerprint Dive into the research topics of 'Biology of Human Papillomavirus Infection and Immune Therapy for HPV-Related Head and Neck Cancers'. Together they form a unique fingerprint.

  • Cite this