Biology of CD34+CD38- cells in lymphohematopoiesis

Enrico M. Novelli, Manuel Ramirez, Curt I. Civin

Research output: Contribution to journalArticlepeer-review

Abstract

Since the discovery of the CD34 stem/progenitor cell antigen, considerable progress has been made in further purifying human lymphohematopoietic stem cells (HSC). These studies have identified a number of antigens which can be targeted to subfractionate the CD34+ cell population. In particular, several lines of evidence suggest that the rare CD38- subpopulation of CD34+ cells may be enriched in HSC. This review briefly summarizes relevant knowledge concerning the CD38 molecule and the results of in vitro and in vivo studies of CD34+38- cells. Possible clinical uses for purified CD34+38- cells are outlined.

Original languageEnglish (US)
Pages (from-to)285-293
Number of pages9
JournalLeukemia and Lymphoma
Volume31
Issue number3-4
StatePublished - 1998

Keywords

  • CD34
  • CD38
  • Hematopoiesis
  • Progenitor cells
  • Stem cells

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Biology of CD34<sup>+</sup>CD38<sup>-</sup> cells in lymphohematopoiesis'. Together they form a unique fingerprint.

Cite this