Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

Uwe Marx, Tommy B. Andersson, Anthony Bahinski, Mario Beilmann, Sonja Beken, Flemming R. Cassee, Murat Cirit, Mardas Daneshian, Susan Fitzpatrick, Olivier Frey, Claudia Gaertner, Christoph Giese, Linda Griffith, Thomas Hartung, Minne B. Heringa, Julia Hoeng, Wim H. De Jong, Hajime Kojima, Jochen Kuehnl, Marcel LeistAndreas Luch, Ilka Maschmeyer, Dmitry Sakharov, Adrienne J A M Sips, Thomas Steger-Hartmann, Danilo A. Tagle, Alexander Tonevitsky, Tewes Tralau, Sergej Tsyb, Anja Van De Stolpe, Rob Vandebriel, Paul Vulto, Jufeng Wang, Joachim Wiest, Marleen Rodenburg, Adrian Roth

Research output: Contribution to journalArticle

Abstract

The recent advent of microphysiological systems-microfluidic biomimetic devices that aspire to emulate the biology of human tissues, organs and circulation in vitro-promises to enable a global paradigm shift in drug development. An extraordinary US government initiative and various dedicated research programs in Europe and Asia recently have led to the first cutting-edge achievements of human single-organ and multi-organ engineering based on microphysiological systems. The expectation is that test systems established on this basis will model various disease stages and predict toxicity, immunogenicity, ADME profiles and treatment efficacy prior to clinical testing. Consequently, this technology could significantly affect the way drug substances are developed in the future. Furthermore, microphysiological system-based assays may revolutionize our current global programs of prioritization of hazard characterization for any new substances to be used, for example, in agriculture, food, ecosystems or cosmetics, thus replacing the use of laboratory animal models. Here, thirty-six experts from academia, industry and regulatory bodies present the results of an intensive workshop (held in June 2015, Berlin, Germany). They review the status quo of microphysiological systems available today against industry needs, and assess the broad variety of approaches with fit-for-purpose potential in the drug development cycle. Feasible technical solutions to reach the next levels of human biology in vitro are proposed. Furthermore, key organ-on-a-chip case studies as well as various national and international programs are highlighted. Finally, a roadmap into the future towards more predictive and regulatory-accepted substance testing on a global scale is outlined.

Original languageEnglish (US)
Pages (from-to)272-321
Number of pages50
JournalAltex
Volume33
Issue number3
DOIs
StatePublished - 2016

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Keywords

  • Drug testing
  • In vitro models
  • Microphysiological systems
  • Organ-on-a-chip
  • Predictive toxicology

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology
  • Medical Laboratory Technology

Cite this

Marx, U., Andersson, T. B., Bahinski, A., Beilmann, M., Beken, S., Cassee, F. R., Cirit, M., Daneshian, M., Fitzpatrick, S., Frey, O., Gaertner, C., Giese, C., Griffith, L., Hartung, T., Heringa, M. B., Hoeng, J., De Jong, W. H., Kojima, H., Kuehnl, J., ... Roth, A. (2016). Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing. Altex, 33(3), 272-321. https://doi.org/10.145/3/aitex.1603161