TY - JOUR
T1 - Biology and genetics of atopic disease
AU - Casolaro, Vincenzo
AU - Georas, Steve N.
AU - Song, Zhimin
AU - Ono, Santa Jeremy
PY - 1996/12
Y1 - 1996/12
N2 - Several immunological disorders including allergic rhinitis, bronchial asthma, atopic dermatitis, food allergies, urticaria, nonhereditary angioedema, systemic anaphylaxis, and allergic conjunctivitis are associated with a positive family history, and share a positive response in the Prausnitz-Kuster (wheal and flare) reaction. Studies have shown that 20-30% of the population has a strong genetic predisposition for this condition; termed atopy, whose hallmark is a greatly elevated serum IgE concentration. A great deal is known about the cellular interactions that mediate the sensitization, immediate and late-phase reactions that follow encounters with allergen, as well as about the cell surface and signaling events that result in mediator release from inflammatory cells. Less is known of the genes that confer genetic predisposition for atopy; however, a worldwide effort to identify atopy genes is making significant progress.
AB - Several immunological disorders including allergic rhinitis, bronchial asthma, atopic dermatitis, food allergies, urticaria, nonhereditary angioedema, systemic anaphylaxis, and allergic conjunctivitis are associated with a positive family history, and share a positive response in the Prausnitz-Kuster (wheal and flare) reaction. Studies have shown that 20-30% of the population has a strong genetic predisposition for this condition; termed atopy, whose hallmark is a greatly elevated serum IgE concentration. A great deal is known about the cellular interactions that mediate the sensitization, immediate and late-phase reactions that follow encounters with allergen, as well as about the cell surface and signaling events that result in mediator release from inflammatory cells. Less is known of the genes that confer genetic predisposition for atopy; however, a worldwide effort to identify atopy genes is making significant progress.
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U2 - 10.1016/S0952-7915(96)80007-0
DO - 10.1016/S0952-7915(96)80007-0
M3 - Article
C2 - 8994858
AN - SCOPUS:0030448828
SN - 0952-7915
VL - 8
SP - 796
EP - 803
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 6
ER -