Biology and genetics of atopic disease

Vincenzo Casolaro, Steve N. Georas, Zhimin Song, Santa Jeremy Ono

Research output: Contribution to journalArticle

Abstract

Several immunological disorders including allergic rhinitis, bronchial asthma, atopic dermatitis, food allergies, urticaria, nonhereditary angioedema, systemic anaphylaxis, and allergic conjunctivitis are associated with a positive family history, and share a positive response in the Prausnitz-Kuster (wheal and flare) reaction. Studies have shown that 20-30% of the population has a strong genetic predisposition for this condition; termed atopy, whose hallmark is a greatly elevated serum IgE concentration. A great deal is known about the cellular interactions that mediate the sensitization, immediate and late-phase reactions that follow encounters with allergen, as well as about the cell surface and signaling events that result in mediator release from inflammatory cells. Less is known of the genes that confer genetic predisposition for atopy; however, a worldwide effort to identify atopy genes is making significant progress.

Original languageEnglish (US)
Pages (from-to)796-803
Number of pages8
JournalCurrent Opinion in Immunology
Volume8
Issue number6
DOIs
StatePublished - Dec 1996

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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