Biologically-cleavable phosphate protective groups: 4-Acyloxy-1,3,2-dioxaphosphorinanes as neutral latent precursors of dianionic phosphates

D. Farquhar, S. Khan, M. C. Wilkerson, B. S. Anderson

Research output: Contribution to journalArticlepeer-review

Abstract

2-Phenoxy-2-oxo-4-pivaloyloxy-1,3,2-dioxophosphorinane (1) was prepared as a stable, neutral precursor of phenyl phosphate. In the presence of 20% human plasma, 1 was converted quantitatively to phenyl phosphate with a half-life of 15 min.

Original languageEnglish (US)
Pages (from-to)655-658
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number5
DOIs
StatePublished - Jan 30 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Fingerprint Dive into the research topics of 'Biologically-cleavable phosphate protective groups: 4-Acyloxy-1,3,2-dioxaphosphorinanes as neutral latent precursors of dianionic phosphates'. Together they form a unique fingerprint.

Cite this