Biological therapies for cardiac arrhythmias: Can genes and cells replace drugs and devices?

Hee Cheol Cho, Eduardo Marbán

Research output: Contribution to journalArticle

Abstract

Cardiac rhythm disorders reflect failures of impulse generation and/or conduction. With the exception of ablation methods that yield selective endocardial destruction, present therapies are nonspecific and/or palliative. Progress in understanding the underlying biology opens up prospects for new alternatives. This article reviews the present state of the art in gene-and cell-based therapies to correct cardiac rhythm disturbances. We begin with the rationale for such approaches, briefly discuss efforts to address aspects of tachyarrhythmia, and review advances in creating a biological pacemaker to cure bradyarrhythmia. Insights gained bring the field closer to a paradigm shift away from devices and drugs, and toward biologics, in the treatment of rhythm disorders.

Original languageEnglish (US)
Pages (from-to)674-685
Number of pages12
JournalCirculation Research
Volume106
Issue number4
DOIs
StatePublished - Mar 2010
Externally publishedYes

Keywords

  • Bradycardia
  • Cell therapy
  • Gene therapy
  • Tachycardia

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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