Patients with breast carcinoma were screened for abnormal concentrations of CEA, HCG, putrescine, spermidine, spermine, pseudouridine, N 2, N 2 dimethylguanosine, and 1 methylinosine. Abnormal polyamine levels occurred in less than 15% of the patients. Among the nucleosides, N 2, N 2 dimethylguanosine was the most frequently abnormal, occurring in 57% of the patients with metastatic disease. CEA levels were abnormal in 30% of postoperative N+ patients and 74% of patients with metastatic disease, while HCG elevations were found in 45% and 50%, respectively. All the patients with one or more marker abnormalities could be detected by measuring only CEA, N 2, N 2 dimethylguanosine, and HCG. Among these 3 tests, a singular marker abnormality occurred in 35.8% of the patients, and all 3 tests were abnormal in 21.8% of the patients. The performance of these 3 tests in each patient revealed one or more abnormalities in 97% of the patients with metastatic disease, and 67% of the postoperative N+ patients.
|Original language||English (US)|
|Number of pages||6|
|Publication status||Published - 1975|
ASJC Scopus subject areas
- Cancer Research