Biological markers in breast carcinoma. I. Incidence of abnormalities of CEA, HCG, three polyamines, and three minor nucleosides

D. C. Tormey, T. P. Waalkes, D. Ahmann, C. W. Gehrke, R. W. Zumwatt, J. Snyder, H. Hansen

Research output: Contribution to journalArticle


Patients with breast carcinoma were screened for abnormal concentrations of CEA, HCG, putrescine, spermidine, spermine, pseudouridine, N 2, N 2 dimethylguanosine, and 1 methylinosine. Abnormal polyamine levels occurred in less than 15% of the patients. Among the nucleosides, N 2, N 2 dimethylguanosine was the most frequently abnormal, occurring in 57% of the patients with metastatic disease. CEA levels were abnormal in 30% of postoperative N+ patients and 74% of patients with metastatic disease, while HCG elevations were found in 45% and 50%, respectively. All the patients with one or more marker abnormalities could be detected by measuring only CEA, N 2, N 2 dimethylguanosine, and HCG. Among these 3 tests, a singular marker abnormality occurred in 35.8% of the patients, and all 3 tests were abnormal in 21.8% of the patients. The performance of these 3 tests in each patient revealed one or more abnormalities in 97% of the patients with metastatic disease, and 67% of the postoperative N+ patients.

Original languageEnglish (US)
Pages (from-to)1095-1100
Number of pages6
Issue number4
Publication statusPublished - 1975
Externally publishedYes


ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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