Biological effects of the Los Alamos meson beam on cells in culture

M. R. Raju; J. F. Dicello; T. T. Trujillo; M. M. Kligerman

doi:10.1148/116.1.191

Biological effects of the Los Alamos meson beam on cells in culture

M. R. Raju, J. F. Dicello, T. T. Trujillo, M. M. Kligerman

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8 Scopus citations

Abstract

Preliminary measurements of the biological effects of negative pions on cells in culture are reported. Cell survival as a function of depth was obtained by using gelatin to suspend the cells. The results indicate that the effects are more pronounced at the peak portion of negative pions. Cell survival curves were also obtained under oxygenated and hypoxic conditions. The biological effectiveness at the peak was found to be a factor of 2.0 higher than at the plateau. The oxygen enhancement ratio was 1.5 at the peak. No significant differences in biological effects were observed above 14 mm in the peak region.

Original language	English (US)
Pages (from-to)	191-193
Number of pages	3
Journal	RADIOLOGY
Volume	116
Issue number	1
DOIs	https://doi.org/10.1148/116.1.191
State	Published - 1975
Externally published	Yes

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1148/116.1.191

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title = "Biological effects of the Los Alamos meson beam on cells in culture",

abstract = "Preliminary measurements of the biological effects of negative pions on cells in culture are reported. Cell survival as a function of depth was obtained by using gelatin to suspend the cells. The results indicate that the effects are more pronounced at the peak portion of negative pions. Cell survival curves were also obtained under oxygenated and hypoxic conditions. The biological effectiveness at the peak was found to be a factor of 2.0 higher than at the plateau. The oxygen enhancement ratio was 1.5 at the peak. No significant differences in biological effects were observed above 14 mm in the peak region.",

author = "Raju, {M. R.} and Dicello, {J. F.} and Trujillo, {T. T.} and Kligerman, {M. M.}",

year = "1975",

doi = "10.1148/116.1.191",

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AU - Raju, M. R.

AU - Dicello, J. F.

AU - Trujillo, T. T.

AU - Kligerman, M. M.

PY - 1975

Y1 - 1975

N2 - Preliminary measurements of the biological effects of negative pions on cells in culture are reported. Cell survival as a function of depth was obtained by using gelatin to suspend the cells. The results indicate that the effects are more pronounced at the peak portion of negative pions. Cell survival curves were also obtained under oxygenated and hypoxic conditions. The biological effectiveness at the peak was found to be a factor of 2.0 higher than at the plateau. The oxygen enhancement ratio was 1.5 at the peak. No significant differences in biological effects were observed above 14 mm in the peak region.

AB - Preliminary measurements of the biological effects of negative pions on cells in culture are reported. Cell survival as a function of depth was obtained by using gelatin to suspend the cells. The results indicate that the effects are more pronounced at the peak portion of negative pions. Cell survival curves were also obtained under oxygenated and hypoxic conditions. The biological effectiveness at the peak was found to be a factor of 2.0 higher than at the plateau. The oxygen enhancement ratio was 1.5 at the peak. No significant differences in biological effects were observed above 14 mm in the peak region.

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Biological effects of the Los Alamos meson beam on cells in culture

Abstract

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