Biological characteristics of [18F]-THK523 for tau imaging

Yan Yan Kong; Zhan Si; Zheng Wei Zhang; Yi Hui Guan; Guo Xian Cao; Fang Ping Xue; Feng Chun Hua; Ping Wu; Jun Zhao; Jian Hua Zhu; Cong Li; Jian Chen; Jun Qian

doi:10.13538/j.1001-8042/nst.25.050302

Biological characteristics of [¹⁸F]-THK523 for tau imaging

Yan Yan Kong, Zhan Si, Zheng Wei Zhang, Yi Hui Guan, Guo Xian Cao, Fang Ping Xue, Feng Chun Hua, Ping Wu, Jun Zhao, Jian Hua Zhu, Cong Li, Jian Chen, Jun Qian

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Reliable and non-invasive diagnostic tools are highly valuable for successful therapeutic strategies for the treatment of Alzheimer's disease (AD). The existence of neurofibrillary tangles (NFTs) consisting of tau protein are one kind of the pathological features of AD, and its level of severity is correlated with the stage of AD. However, no clinically approved positron emission tomography (PET) probe is currently available for selective imaging of neurofibrillary tangles on patients. In this paper, we report our studies on biological characteristics of [¹⁸F]-THK523 as a novel tau imaging probe. With low molecular weight, [¹⁸F]-THK523 is stable, electrically neutral, lipophilic and non-mass concentration-dependent. Preliminary biological studies have shown the excellent properties of [¹⁸F]-THK523 as brain imaging tracer for further research.

Original language	English (US)
Article number	050302
Journal	Nuclear Science and Techniques
Volume	25
Issue number	5
DOIs	https://doi.org/10.13538/j.1001-8042/nst.25.050302
State	Published - Sep 15 2014
Externally published	Yes

Keywords

Alzheimer's disease (AD)
Biological characteristics
Neurofibrillary tangles (NFTs)
Tau-specific probe
[F]-THK523

ASJC Scopus subject areas

Nuclear Energy and Engineering
Nuclear and High Energy Physics

Access to Document

10.13538/j.1001-8042/nst.25.050302

Cite this

@article{81adee01a1f846719adeeeb5263a690a,

title = "Biological characteristics of [18F]-THK523 for tau imaging",

abstract = "Reliable and non-invasive diagnostic tools are highly valuable for successful therapeutic strategies for the treatment of Alzheimer's disease (AD). The existence of neurofibrillary tangles (NFTs) consisting of tau protein are one kind of the pathological features of AD, and its level of severity is correlated with the stage of AD. However, no clinically approved positron emission tomography (PET) probe is currently available for selective imaging of neurofibrillary tangles on patients. In this paper, we report our studies on biological characteristics of [18F]-THK523 as a novel tau imaging probe. With low molecular weight, [18F]-THK523 is stable, electrically neutral, lipophilic and non-mass concentration-dependent. Preliminary biological studies have shown the excellent properties of [18F]-THK523 as brain imaging tracer for further research.",

keywords = "Alzheimer's disease (AD), Biological characteristics, Neurofibrillary tangles (NFTs), Tau-specific probe, [F]-THK523",

author = "Kong, {Yan Yan} and Zhan Si and Zhang, {Zheng Wei} and Guan, {Yi Hui} and Cao, {Guo Xian} and Xue, {Fang Ping} and Hua, {Feng Chun} and Ping Wu and Jun Zhao and Zhu, {Jian Hua} and Cong Li and Jian Chen and Jun Qian",

year = "2014",

month = sep,

day = "15",

doi = "10.13538/j.1001-8042/nst.25.050302",

language = "English (US)",

volume = "25",

journal = "Nuclear Science and Techniques",

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T1 - Biological characteristics of [18F]-THK523 for tau imaging

AU - Kong, Yan Yan

AU - Si, Zhan

AU - Zhang, Zheng Wei

AU - Guan, Yi Hui

AU - Cao, Guo Xian

AU - Xue, Fang Ping

AU - Hua, Feng Chun

AU - Wu, Ping

AU - Zhao, Jun

AU - Zhu, Jian Hua

AU - Li, Cong

AU - Chen, Jian

AU - Qian, Jun

PY - 2014/9/15

Y1 - 2014/9/15

N2 - Reliable and non-invasive diagnostic tools are highly valuable for successful therapeutic strategies for the treatment of Alzheimer's disease (AD). The existence of neurofibrillary tangles (NFTs) consisting of tau protein are one kind of the pathological features of AD, and its level of severity is correlated with the stage of AD. However, no clinically approved positron emission tomography (PET) probe is currently available for selective imaging of neurofibrillary tangles on patients. In this paper, we report our studies on biological characteristics of [18F]-THK523 as a novel tau imaging probe. With low molecular weight, [18F]-THK523 is stable, electrically neutral, lipophilic and non-mass concentration-dependent. Preliminary biological studies have shown the excellent properties of [18F]-THK523 as brain imaging tracer for further research.

AB - Reliable and non-invasive diagnostic tools are highly valuable for successful therapeutic strategies for the treatment of Alzheimer's disease (AD). The existence of neurofibrillary tangles (NFTs) consisting of tau protein are one kind of the pathological features of AD, and its level of severity is correlated with the stage of AD. However, no clinically approved positron emission tomography (PET) probe is currently available for selective imaging of neurofibrillary tangles on patients. In this paper, we report our studies on biological characteristics of [18F]-THK523 as a novel tau imaging probe. With low molecular weight, [18F]-THK523 is stable, electrically neutral, lipophilic and non-mass concentration-dependent. Preliminary biological studies have shown the excellent properties of [18F]-THK523 as brain imaging tracer for further research.

KW - Alzheimer's disease (AD)

KW - Biological characteristics

KW - Neurofibrillary tangles (NFTs)

KW - Tau-specific probe

KW - [F]-THK523

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