Biological characteristics of [18F]-THK523 for tau imaging

Yan Yan Kong, Zhan Si, Zheng Wei Zhang, Yi Hui Guan, Guo Xian Cao, Fang Ping Xue, Feng Chun Hua, Ping Wu, Jun Zhao, Jian Hua Zhu, Cong Li, Jian Chen, Jun Qian

Research output: Contribution to journalArticlepeer-review

Abstract

Reliable and non-invasive diagnostic tools are highly valuable for successful therapeutic strategies for the treatment of Alzheimer's disease (AD). The existence of neurofibrillary tangles (NFTs) consisting of tau protein are one kind of the pathological features of AD, and its level of severity is correlated with the stage of AD. However, no clinically approved positron emission tomography (PET) probe is currently available for selective imaging of neurofibrillary tangles on patients. In this paper, we report our studies on biological characteristics of [18F]-THK523 as a novel tau imaging probe. With low molecular weight, [18F]-THK523 is stable, electrically neutral, lipophilic and non-mass concentration-dependent. Preliminary biological studies have shown the excellent properties of [18F]-THK523 as brain imaging tracer for further research.

Original languageEnglish (US)
Article number050302
JournalNuclear Science and Techniques
Volume25
Issue number5
DOIs
StatePublished - Sep 15 2014
Externally publishedYes

Keywords

  • Alzheimer's disease (AD)
  • Biological characteristics
  • Neurofibrillary tangles (NFTs)
  • Tau-specific probe
  • [F]-THK523

ASJC Scopus subject areas

  • Nuclear Energy and Engineering
  • Nuclear and High Energy Physics

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